Lecture one: phylogeny review & virology Flashcards
systematics
study of diversity of organisms & evolutionary relationships
2 parts of classification
taxonomy & phylogeny
taxonomy
naming describing and classifing
binomial classification
each species has a unique 2 part name: genus and specific epithet
made by: carolus Linnasue
ex. hom sapiens
two parts of hierachical classification
species: & hierarchy
each level is more inclusive than the one below
levels of classification
domian,kingdom,phylum,class,order,family
genus, species
(dear king philp come out for goodness sake)
phylogeny
revolutionary history of species or group
taxon
grouping at any level
clade
group of species that includes ancestral species and all of its descendants (monophyletic group)
phylogenetics
study of evolutionary history of species or group of species
phylogenetics are based on
homologous characters
phenotypic & genetics similarities due to shared ancestry
characters are
defined attributes of species state
alternate forms of a character ex: 4 legs, present vs absent
homologous characters
- inherited from common ancestor
- look different and have different functions
- underlying patterns of bone, muscles & nerves are the same
analogous characters
- independently acquired
- similar adaptations in organisms from different lineages
- similar environment, selection pressure & characters
- convergent evolution
- similar structure that serve same function but doesn’t have the history
evolution
- genetic changes and alle freq whitin a population
- no changes in individuals
natural selection
- acts on variation
- preserves benficial
- removes detrimental
obligate intracellular parisite
- invade susceptible host cells
- cannot carry out metabolic actvites on thier own
- survive only by using resources of host cells
- cannot reproduce on its own
capsids
- protien coats that surround genetic material
- capsomere - protien subunit
- determin shape
- contains host and virus protien
virus replication cycle
- binds to host cell
- viral genome enters cell (injected, endocytosis, enveloped virus - fused w/ plasma membrane)
- genome replication + gene expression
- assembly
- exit : blob off, transport proteins, lyse
lytic cycle
ends in host cells death - virulent phage
lytic cycle steps
- phage infects cell
- phage DNA circularizes ( separates from host DNA)
- Phage replicates
- cell lyses releasing phage
bacterial defenses
mutants that don’t have surface receptors
not recgonized by virus
restriction enzymes
- recognizes foreign DNA and CO+
- Bacterial DNA protected by methylation
lysogenic cycle
- replication of phage genome w/o destroying host cell
- temperate phage
prophage integrated virus
- codes for proteins that prevents transcription of most other viral genes
- does not enter lytic cycle
- replicates along with host chromosome
- can remain indefinitely
host cell is good & the environment is good
lysogenic cycle
unhealthy host =
lytic cycle