Lecture 9 - Stomach Disease (Part II)

Question 1

Helicobacter Pylori diseases?

Answer 1

Gastritis, Peptic ulcer disease, gastric cancer, gastric MALToma

Question 2

H. Pylori action?

Answer 2

Invades protective barrier, exposes mucosa to acid, causing inflammation and difficulty healing - typically asymptomatic

Question 3

Treatment of H. Pylori?

Answer 3

Triple therapy: omeprazole, clarithromycin and amoxycillin for 2 weeks

Question 4

Other causes of peptic ulcer disease?

Answer 4

NSAIDs, Aspirin

Question 5

Surgeries to historically treat ulcer disease?

Answer 5

Gastrectomy, Vagotomy, Pyloroplasty (cut pylorus and re-suture to relax pyloric sphincter

Question 6

Intestinal Gastric adenocarcinoma?

Answer 6

well differentiated, cells arranged in tubular pattern

Question 7

Diffuse Gastric adenocarcinoma?

Answer 7

Poorly differentiated, lack glandular formation, infiltrate gastric wall (linitis plastina)

Question 8

H. Pylori leading to gastric cancer?

Answer 8

Widespread inflammation leads to destruction of parietal cells causing bacteria survival and build up leading to cancer