Lecture 7 -Lymphatic System Flashcards
What does the lymphatic system comprise of?
Lymph vessels, lymphatic organs and diffuse lymphatic tissue
What are the three general functions and features of lymph vessels
- Collection of tissue fluid and return to systemic circulation
- Transport of lymphocytes and other cells
- Uptake and transport of long chain fatty acids absorbed in intestine
What is the composition of tissue fluid/plasma (3)
Water, proteins, lipids extruded from blood capillaries into connective tissue matrix
How is 20% of tissue fluid returned to main systemic circulation
Lymph vessels
What happens to the other 80% of tissue fluid not returned
Removed via blood capillaries and perspiration
What is lymphoedema
Compromised fluid or protein return
Where is the majority of lymph returned to the venous system
- Junction of subclavian and internal jugular veins (usual)
2. Additional: IVC, renal and suprarenal, azygous and iliac veins but also lymph nodes
Where are lymphocytes produced
Lymph nodes along the course of larger lymph vessels and by other lymphatic organs and tissue such as spleen and gut associated lymphatic tissue (GALT)
How long do FAs havae to be to be absorbed by intestinal epithelial cells and transported into extracellular space + lymph vessels of intestinal villi
more than 12 carbon atoms
Where is lymph transported to from lymph vessels of intestinal villi /lacteals
Thoracic duct and ultimately blood stream
Where do smaller fatty acids less than 12 carbons go
Taken into blood stream and then portal vein and liver
What are lymph capillaries?
Blindly ending tubes in connective tissue which are initially a plexus which anastamose to form larger vessels
Which lymph vessel is the larger and what is its diameter
Throacic duct
2-5mm in diameter
Lymph vessels have thick walls
False
What are characteristics of lymph fluid return
Gravity
Pressure from adjacent organs
Viscera
Valves
Larger lymph vessels have their own blood supply of small vessels forming a plexus true or false
True
Lymph vessels do not repair after damage
False, repair is rapid especially in smaller vessels
Lymph vessels do not follow large blood vessels true or false
False, often follow large blood vessels as a plexus on adventitia
Lymph vessels are difficult to recognise in classical divisions, how are they usually sutdied
Dyes, coloured latex or radioopaque material (lipidol) in conjunction with x-rays
Lymph vessels are not found in: (3)
CNS
Bone marrow
Avascular tissue - cornea, epidermis, cartilage
Lymph vessels are often associated with?
Lymph nodes
What is a general length of lymph organs/nodes
1-25mm
What do lymph nodes contain
Proliferative structures - lymph nodules
What do lymph nodules produce
Lymphocytes, other cells of the immune system which are involved in immunosurveillance of lymph or added back to lymph (lymphocytes)
How many lymph nodes are there around
300-400
Where are most of the lymph nodes
Neck, thorax, abdomen, pelvis and groin
Relatively few in limbs
How are lymph nodes named
Whether they are superficial/deep
Associated structures
Lymph nodes are always situated along most lymph vessels true or false
True
How do lymph vessels associate with nodes
Vessels divide into a number of afferent branches which penetrate the capsule of the node
What does lymph do in the node
Percolates sinuses and collects lymphocytes produced by the node and leaves via one or several efferent vessels
What else do lymph nodes produce that arent lymphocytes
Macrophages and plasma cells which are involved in immunosurveillance of lymph
What are lymph nodes not associated with
Lymph capillaries and the smallest lymph vessels or the thoracic duct or right lymphatic duct (if present)