Lecture 6 Flashcards
what is sustained release
form formulated to slow the release of a therapeutic agent and plasma profile sustained
what is controlled release
goes beyond sustained release and implies reproducibility and predictability
T/F controlled release allows us to maintain a narrow drug plasma concentration- steady state
True
what are some examples of controlled release drugs
coated beads, multitablet system, microencapsulated drugs
what is steady state
the rate going into the body must be equal to the disposition
what characteristics of drugs are best for oral controlled release
neither fast or slow absorption and release, absorbed in GI, small does
what are some physiological factors affecting absorption
surface area, residence time, pH, permeability, dietary
T/F epithelial cells are polarized with directional transport
True
what are the types of epithelia cells
simple squamous, simple columnar, translational, stratified squamous
simple squamous cells are
flattened cells that are relatively permeable
simple columanr cells are
found in GI tract
translational cells are
several layers with different shapes required to stretch
stratified squamous cells are
multiple layers of squamous cells that cover areas intended for wear and tear
the cell membrane is
a semi-permeable membrane fast passage for some and no passage for others
T/F cellular lipid composition is polarized
True
