lecture 3

Question 1

what is drug product performance

Answer 1

the ability of the drug to elicit a therapeutic response and stay in a safe therapeutic range

Question 2

what is the goal of formulations

Answer 2

to transfer a new therapeutic compound and develop a reproducible dosage form

Question 3

T/F a drug performance needs to lack a toxic and non-efficacious response

Answer 3

True

Question 4

What processes describe drug product performance

Answer 4

pharmacokinetics and pharmacodynamics

Question 5

what is the goal of formulations

Answer 5

to transfer a new promising therapeutic compound and develop a reproducible dosage form

Question 6

what does reproducible refer to

Answer 6

containing the same amount of drug and same performance in the body

Question 7

T/F absorption begins declining as disposition begins to increase

Answer 7

true

Question 8

what is druggability

Answer 8

to look at binding as well as drug-like properties that are favorable for product translation

Question 9

what is developability

Answer 9

means to characterize if the new molecules can be formulated

Question 10

druggability includes

Answer 10

the discovery stage, ability to bind, and in vivo models

Question 11

developability includes

Answer 11

drug performance, soluability and dissolution and ADMET

Question 12

T/F drugability needs to be found then developbility can continue

Answer 12

true

Question 13

what is a druggable protein

Answer 13

proteins that can bind drug-like compunds with binding affinity below 10 mM

Question 14

what are the stages of drugability

Answer 14

gene to protein to pharmacophore

Question 15

why are new chemical entities generated

Answer 15

to fit a pharmacophore

Question 16

T/F good drugable entities always mean the drug will be advanced

Answer 16

False, it does not always mean they will be advansed