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dosage > FINAL L1 - Innovation > Flashcards

FINAL L1 - Innovation Flashcards

1
Q

Innovations

A

Oros
Prodrugs
Combination products
Abuse deterrent
ADHD
Oral Vaccines
Sustained Release (Pulsatile)
Enteric
Inhalable
Fentanyl buccal
Fentana Patch
Solid Lipid Nanoparticles

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2
Q

Four Main types of Covid Vaccines in development:

A

mRNa
Vector Vaccines
Protein subunit vaccine
Whole, killed vaccine

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3
Q

mRna vaccine

A

Use mRNA to make a piece of the coronavirus spike. Will get attention of the immune system

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4
Q

Vector vaccine

A

Use another virus to carry in the genetic instructions to make spike protein

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5
Q

Protein subunit vaccine

A

Get little pieces of the target virus circulating in the system for the immune system to find and recognize

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6
Q

Whole, killed vaccine

A

Whole inactivated virus vaccines take longer to make because batches of the coronavirus must first be grown then killed using a chemical or heat, then made into a vaccine that can be injected to elicit an immune response

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7
Q

ADHD Drugs - Methylphenidate

A

(Look at table slide 5) Duration: avg. 3-5 hrs
Initial dose - 5-20 mg
Usual dosing range: 20-72mg/day

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8
Q

ADHD Drugs - Amphetamine based

A

(Look at table slide 6): Duration: 4-12 hrs
Initial dose: 2.5 mg every AM once or twice daily; to 20-30-70 mg caps
Usual dosing range: 10-40mg/30mg per day

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9
Q

ADHD Drugs - Nonstimulant

A

Intuniv (guanfacine XR)
Initial dose: 1 mg in the AM, titrate. Up to 24 hrs
Usual dosing range/max dose: Titrate

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10
Q

Dissolution testing

A

One of 5 main methods for insuring quality of tablets and capsules
(others are assay, impurities, content uniformity, and water)

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11
Q

T/F: Dissolution testing is the only method that can be linked to blood levels and bioavailability

A

True

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12
Q

T/F: Tablet must first disintegrate to go through with disintegration

A

True

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13
Q

The dissolution of the drug in the GI fluids must….

A

Occur before absorption can occur

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14
Q

Drugs high water solubility generally exhibit

A

Few formulation problems

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15
Q

For drugs of low water solubility the absorption rate may be…

A

Governed by the dissolution rate. in such cases, if dissolution occurs too slowly, absorption efficiency may suffer

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16
Q

Dissolution experiment:

A

Place tablet in dissolution apparatus
Measure rate of dissolution
Same as placing in a glass of water
Dissolution test measure rate of release of drug from a tablet

17
Q

High solubility high permeability drugs require…

A

The least rigorous dissolution test

18
Q

More rigorous dissolution testing is required for…

A

High solubility low permeability drugs

19
Q

The MOST rigorous dissolution testing is required for…

A

Low solubility high permeability drugs. These are BCS Class 2 Drugs

20
Q

Metadate CD

A

Look at Chart (Slide 15?)

21
Q

Know how to compare dissolution rates

A

-

22
Q

Steps in Film Coating

A

-Spray solution or dispersion of polymer, solvent, and plasticizer on to tablet
-Solution “wets” surface and spreads
-Solvent evaporates
-Polymer molecules “entangle”
-Film forms through coalescence
-Adhesion takes place between the coating and the surface

23
Q

Know process/components of fluid bed coating

A

-

24
Q

Polymers for film coating - nonenteric

A

-HPMC
-Methyl -Hydroxyethylcellulose
-Ethylcellulose
-HPC

25
Q

Enteric Polymers

A

-Release drug in small intestine
-The omeprazole story
-Acrylate Polymers (Eudragit L and Eudragit S)
-CAP
-HPMCP
-PVAP

26
Q

Matrix Tablet

A

Drug Embedded in polymer matrix

27
Q

Know Process of Matrix Tablet diagram

A

-

28
Q

Elementary Osmotic Pump (EOP) in concerta

A

Components:
-Delivery orifice
-Semipermeable membrane
-Drug-Containing Osmotic Core
allows water in

29
Q

Look at diagram of EOP single chamber vs double chamber process

A

Slide 38

30
Q

T/F: In dissolution there is no metabolism or excretion. All drug remains

A

True

31
Q

For blood levels the drug is metabolized and excreted - goes to

A

0

dosage (30 decks)

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