EXAM2 L5 Flashcards
Drugs and Solubility
Review equations for solubility for weak acid (can’t format properly on here)
Slide 26-28
If pH«pKa, solubility is nearly ______ of pH
independent
T/F: Solubility increases as pH decreases
False; solubility increases as pH increases
T/F: Indefinite solubility increase is truncated by precipitation of a salt
True; (diff. salts have different solubilities)
Crystalluria is
The formation of crystals in the urine
pH of urine
4.5-8
Ionized compounds are/are not reabsorbed in distal tubule?
Are not
Rate of clearance cant be impacted by urine pH due to
Variation in ionization state of drug
T/F: Urine pH can be deliberately altered (i.e. by admin. of sodium bicarbonate) in order to enhance or retard clearance
True
Enteric coating
A salt is formed by
Acid base reaction involving either proton donation or proton acceptance
Typical Pharmaceutical salts
Strong acid + Strong Base
Strong Acid + Weak Base
Weak acid + Strong Base
Weak Acid + Weak Base
What % of drugs are administered as salts?
50%
Salt formation modifies what properties of drugs?
Solubility, crystallinity, particle size, bulk, density
Common reasons for salt formation
Bioavailability
Developability
Purification
Intellectual property