lecture 2 Flashcards
why do we care about drug solubility
need to be fluid for absorption, distribution, reaching sites and elimination
what are some issues with solubility
body is predominantly aqueous, many drugs are hydrophobic and difficult to solubilize
T/F the stronger the crystal the more difficult for the solute molecules to dislodge
true
what reduces solubility
difficulty of dislodging from crystal, and diff solvating dislodged molecules
T/F even mixing well with solvent a strong stable crystal gives difficulty in solubility
true
solid to liquid is
crystallinity
liquid to solution with solvent added is
hydrophobicity
T/F like dissolves like
false, its only half true
T/F the higher the melting point of a solid, the lower its solubility in general
true
what factors can affect dissolution from the drug
solubility, particle size, pH, type of solid
what factors can affect dissolution from the dosage form
solubility, particle size, pH, type of solid, disintegration rate, excipients, manufacturing conditions
changing particle size increases what
the surface are
how much of all drugs in the market are formulated as salts
50%
T/F salt formation is the most straightforward means of making a solid drug
True
how is the drug made if acidic
by crystalizing it from a solution having a pH greater then the pKa of the drug
