Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Histology > Lecture 5: CAMs > Flashcards

Lecture 5: CAMs Flashcards

1
Q

Calcium independent CAMs

A

Integrins

Immunoglobulin superfamily molecules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is fibronectin

A

Protein made up of two polypeptide chains cross-linked by disulfide bonds

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Gap junction function

A

Composed of molecular pores that allow cells to rapidly exchange ions and small molecules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Classes of cadherins and their locations

A

E-Cadherins–Epithelial tissues
N-Cadherins–Nerve cells
P-Cadherins–Pacenta

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Laminin has binding sites for

A

Integrins
Type IV collagen
Entactin
Proteoglycans

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Classes of Selectins and their functions

A

P-Selectins–Associated with platelets
E-Selectins–Associated with activated endothelial cells
L-Selectins–Associated with leukocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Function of integrins in hemidesmosomes

A

Link the basil domain of the cell to the extracellular matrix via the intercellular tonofilamints (intermediate filaments such as keratin)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Components of basil lamina

A 
Laminin
Fibronectin
Type IV collagen
Entactin
Proteoglycans
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Selectin function

A

Selectins are involved in the movement of leukocytes from blood to tissues (extravasation)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Members of immunoglobulin superfamily and function

A

N-CAM- Neural adhesion molecues
I-CAM1- Facilitates transendothelial migration of leukocytes
I-CAM2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Nonclassical cadherins

A

Include desmocollins and desmogleins

Found in desmosomes (macula adherens)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

E-Cadherins

A

Most common type

Loss of E-Cadherin is associated with invasive behavior of tumor cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Basement membrane components

A

Basil lamina

Reticular lamina

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Hemidesmosomes structure/function

A

Link basal domain to basal lamina via intermediate filaments which associate with intracellular plaques which associate with integrin and anchoring filaments (laminin 5)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What are integrins

A

Glycoproteins that are mainly involved in cell-extracellular matrix interactions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Gap junctions are composed of ____ , which form what

A

Connexons, form hydrophillic intercellular channel between adjacent cells

17
Q

Integrins bind what together

A

Extracellular matrix molecules and the cytoskeleton

18
Q

Three chains of laminin

A

Alpha
Beta
Delta

19
Q

Zonula-type of junction, function, filament association

A

Adheren or occluden
Travel all the way around the circumference of the cell and link all neighboring cells to the central cell (belt-like)
Associated with intracellular actin

20
Q

What are Catenins

A

Small proteins that link the cytoplasmic end of a cadherin with the cytoplasmic actin

21
Q

Focal adhesions

A

Spots that anchor the cell to the extracellular matrix via integrins

22
Q

What is the CRD

A

Carbohydrate recognition domain-binding site for carbohydrates on selectins
Calcium is required for binding

23
Q

Basil lamina produced by

A

Epithelium

24
Q

Zonula occluden structure/function

A

Belt-like structure preventing paracellular transport
Associated transmembrane proteins include occludens and claudins. They attach intracellularly to zonula occluden proteins ZO-2 & ZO-3, which attach to actin

25
Q

Reticular lamina produced by

A

Connective tissue

26
Q

Why are selectins classified as lectins

A

Because they bind to carbohydrates

27
Q

Adheren function and location

A

Anchor cells together and reinforce the physical integrity of tissues and cells that make up tissues
Found on basolateral domain of epithelial cells

28
Q

Calcium dependent CAMs

A

Cadherins

Selectins

29
Q

Connexons are composed of

A

6 Connexins

30
Q

Cadherin proteins are anchored by

A

Intracellular plaques

31
Q

Adherens characterized by

A

Intercellular spaces which are filled with cadherin proteins desmogleins and desmocollins

32
Q

Macula- type of junction, function, filament association

A

Adheren (often referred to as desmosomes or hemides)
A “spot” or snap-like junction
Associated with intracellular intermediate filaments
(tonofilaments)

33
Q

Pemphigus foliaceus

A

Autoantibody-mediated blistering disease in which antibodies against desmoglein-1 cause a loss of adhesion of keratinocytes in the superficial layers of epidermis

34
Q

Extracellular domain of integrins bind to what

A

Extracellular matrix molecules such as fibronectin and laminin

35
Q

Categories of junctional complexes

A

Adherens
Occludens
Gap junctions

36
Q

Fibronectin has binding sites for

A

Integrins
Collagen
Heparin (proteoglycan)
Fibrin

37
Q

Major component of basil lamina

A

Laminin

38
Q

Forms of fibronectin

A

Cellular (produced by fibroblasts)

Plasma

39
Q

Occluden function

A

Establish impermeable barrier between adjacent cells
Maintains concentration differences between
environments on either side of epithelial sheets

Histology (24 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions