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Histology > Lecture 13: Hematopoiesis > Flashcards

Lecture 13: Hematopoiesis Flashcards

1
Q

Totipotent

A

Give rise to all cells of an organism

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2
Q

Pluripotent

A

Give rise to all cells of the embryo and subsequently adult tissues

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3
Q

Multipotent

A

Give rise to different cell types of a given lineage

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4
Q

Embryonic stem cells

A

Pluripotent

Derived from inner-cell mass of blastocyst

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5
Q

Adult stem cells

A

Multipotent

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6
Q

Hematopoietic site 2-8 weeks gestation

A

Islands of hematopoiesis are found in the yolk sac wall
Give rise to nucleated erythrocytes
No leukocytes yet

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7
Q

Hematopoietic site 8-28 weeks gestation

A

Hematopoiesis first occurs in the liver and then the spleen

Normally ceases around time of birth

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8
Q

Hematopoietic site 6 months gestation to birth and beyond

A

Hematopoiesis occurs in red bone marrow

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9
Q

Red marrow found where prior to and after puberty

A

Prior- Skull, ribs, sternum, vertebrae, clavicles, pelvis, long bones
After- Same except not in long bones

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10
Q

Red blood cell formation can occur where in certain disease states

A

Liver and Spleen

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11
Q

Stroma

A

Contains fibroblasts, reticular, adipose and endothelial cells
Synthesizes and secretes hematopoietic growth factors

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12
Q

Parenchyma

A

Consists of various lineages of hematopoietic cells in different stages of differentiation

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13
Q

Sinusoids

A

Endothelial-lined spaces that connect arterial and venous vessels
Provides access for mature blood cells to move into the circulation

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14
Q

Hematopoietic cords

A

Bands of parenchyma and stroma lying between the sinusoids

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15
Q

Hematopoietic stem cells are (potency)

A

Pluripotent

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16
Q

Hematopoietic stem cells give rise to

A

Myeloid stem cells- give rise to all blood cell lines besides lymphocytes
Lymphoid stem cells- give rise to lymphocytes

17
Q

Leukocytes include

A

Granulocytes and agranulocytes

18
Q

Granulocytes include

A

Neutrophils, basophils, Eosinophils

19
Q

Agranulocytes include

A

Monocytes, lymphocytes

20
Q

Myeloid stem cells give rise to

A 
Erythroid CFU- Produce RBC
Megakaryocyte CFU- Produce RBC
Basophil CFU-WBC
Eosinophil CFU-WBC
Granulocyte-macrophage CFU-WBC
21
Q

Lymphoid stem cells give rise to what, which mature where

A

T-cell progenitor- matures in thymus

B-cell progenitor- matures in bone marrow

22
Q

Cells normally found in circulation

A 
Monocyte
Band cell
Neutrophil
Platelets
Eosinophil/basophil
Reticulocyte
Erythrocyte
23
Q

Cells which can divide

A 
Monoblast
Myeloblast
Premyelocyte-myelocyte
Proerythroblast
Basophilic erythroblast
Polychromatophilic erythroblast

Histology (24 decks)

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