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Tissue Engineering and Regenerative Medicine > Lecture 5 > Flashcards

Lecture 5 Flashcards

1
Q

What is gene therapy? Define?

A

wasdadsa

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2
Q

What are the types of gene therapy? What are the properties of each?

A

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3
Q

What is nature’s version of gene therapy?

A

saasddas

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4
Q

What needs to be considered to make gene therapy successful?

A

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5
Q

How to get DNA into cells? What methods were tried? What are the advantages and disadvantages?

A

dadasdads

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6
Q

What is naked DNA- to get DNA into cells? Properties? Success?

A

edasdasd

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7
Q

How were liposomes used to get DNA into cells? Properties? Success?

A

edwasdasd

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8
Q

What are viral vectors? How do they help get DNA into cells?

A

sadasdasd

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9
Q

What are the subdivisions? Which viral vectors go into these divisions? Properties?

A

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10
Q

What is a viral titre? How is it made? What is the end product?

A

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11
Q

What are integrating viral vectors? RNA/DNA? What are the types?

A

dasdasd

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12
Q

What is the process of integrating viral vectors?

A

dasadasda

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13
Q

What is a negative aspect of the integrating viral vectors?

A

edasdada

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14
Q

What are the non-integrating viral vectors? RNA /DNA? What are the types?

A

wdadadsad

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15
Q

What are the benefits? What are the disadvantages of the different types?

A

dasdasdad

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16
Q

What is the process of gene transfer?

A

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17
Q

What is conditioning?

A

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18
Q

What is a good place for in vivo gene transfer? What are the properties that make it a good place?

A

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19
Q

What is immune privileged organ?

A

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20
Q

What is an example of in vivo gene transfer?

A

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21
Q

What viruses are best for retinal diseases? Why?

A

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22
Q

What is ex-vivo gene transfer? Example?

A

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23
Q

What is Strimvelis? What is new about it? How does it work?

A

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24
Q

What is the whole process of ex-vivo gene transfer?

A

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25
Q

What is in Vivo-siRNA transfer? What is the process? What disease can it be used for?

A

edsasds

26
Q

What is a dominant negative mutation?

A

wdasadasd

27
Q

When is the phenotype of PPK seen? What stage in life? Why?

A

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28
Q

Summary of gene transfer? What is it used for? What are the advantageous? What are the disadvantages?

A

edasdadas

29
Q

What is gene correction?

A

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30
Q

What is the idea behind gene correction?

A

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31
Q

What is the whole process of gene correction? What factors need to be considered?

A

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32
Q

What revertant mosaicism? What is the process using an example?

A

edadadasd

33
Q

Where specifically does revertant mosaicism occur?

A

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34
Q

How does revertant mosaicism occur in EB?

A

edasdasd

35
Q

How can we use revertant mosaicism for cell therapy in EB?

A

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Tissue Engineering and Regenerative Medicine (17 decks)

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