Lecture 14 Flashcards
What is the current drug development process? What is tested at each stage?
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What are the drugs tested on?
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What is the problem with the drug development process? What does this show? What are you losing out on?
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If a drug is repackaged what is different about the clinical trials process?
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What would be a new way of drug development that would help assess toxicity?
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What is the DARPA initiative? When was it? What did they want?
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What would be the use of the organ-on-chip system? What would be the benefit of creating a whole system in comparison to just one organ on a chip?
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What were the two types of organ-on -chip systems which was created?
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What was the NCAT initiative? What was different about this organ-on-chip system?
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What is the cardio-pulmonary system? What is needed to be mimicked?
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What is the function of a lung? What is the cellular structure and properties?
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What is the criteria for the tissue when making a lung on chip? What is the criteria for the chip?
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What was the lung on chip design structure?
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What were the cells which were grown on different layers? What were the signals given to the structure?
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What happened as a results of the air interface? What other features developed making the system resemble alveoli?
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What is a normal phenomenon which happens in inhalation in the lungs? How was this replicated in the lung on chip design?
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What physiological response was replicated in the lung on chip system?
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What is pulmonary inflammation?
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How was this replicated in the lung on chip system?
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What was another way to show pulmonary inflammation response in the lung on chip system? What was found to improve this response?
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How was oedema promoted in the lung on chip system?
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What is the criteria for the tissue and chip for a heart on a chip?
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How is the cardiac tissue aligned in the body? How is it aligned in culture? What is the consequence of this difference in alignment?
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What is the design of the heart on a chip? How do they get the cells onto the chip? How to they get the cells to stick on? How do the cardiomyocytes align?
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How were the cells made into chips which had contractility? What did the different states represent?
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What did each film represent?
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Define Systole? Define Diastole?
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How did the architecture and alignment change with different fibronectin properties?
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What is a consequence of an isotropic cellular alignment?
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What is the heart on a chip’s response to adrenaline?
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What is the goal now with the lung and heart chips?
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What can be done with this in the future?
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