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Tissue Engineering and Regenerative Medicine > Lecture 15 > Flashcards

Lecture 15 Flashcards

1
Q

What happens to a drug after it is ingested? What is the journey it takes through?

A

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2
Q

What does reduced adsorption of the drug across the gut lead to?

A

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3
Q

What is first pass metabolism?

A

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4
Q

What is a pro-drug?

A

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5
Q

What are the different ways in which drugs are administrated, distributed and eliminated? What is the flow chart between them?

A

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6
Q

What is drug recall? How often does it happen? What are the reasons?

A

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7
Q

What are the main adverse effects which lead to drug recall?

A

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8
Q

What is hepatotoxicity?

A

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9
Q

What is Cardiotoxicity?

A

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10
Q

What is Nephrotoxicity?

A

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11
Q

What is Dermatological toxicity?

A

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12
Q

How likely to predict how badly someone would respond to a drug?

A

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13
Q

What can multiple organs together on a chip be used for?

A

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14
Q

How to check the effects of a failing kidney?

A

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15
Q

How to check whether the metabolites from the liver is toxic to the heart?

A

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16
Q

How to check whether other organs/tissues are affects by a particular drug?

A

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17
Q

What about warfare? How are organs on chips be able to be used for it?

A

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18
Q

Where is the research going with organs on chips?

A

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19
Q

What needs to be considered if focusing on integrating systems onto one chip?

A

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20
Q

What cell types can be inputted into organ chips? What would this mean the future of?

A

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21
Q

What is an example of integration of organs together onto one chip? What were they focusing on?

A

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22
Q

What were the requirements of the system therefore?

A

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23
Q

How was the bioassay developed? What is the structure like?

A

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24
Q

What were the specific target cells?

A

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25
Q

What were the goals?

A

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26
Q

Why this system may not be the best and is faulted at some point? What is a solution to this especially in the context of breast cancer cells?

A

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27
Q

How did they assemble and develop the bioassay system representing the intestine, liver and breast cancer tissue?

A

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28
Q

What are the ways in which the Bioassay could be assessed whether the different cell types are doing anything?

A

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29
Q

What were the two drugs which was used to test the system?

A

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30
Q

What did the system show about the two drugs?

A

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31
Q

What does this mean about the system?

A

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32
Q

How could the system be improved though?

A

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33
Q

What are other groups trying to do to make a system in a different way?

A

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34
Q

What is the problem with this?

A

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35
Q

What are the goals?

A

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36
Q

What is the vascular network like in actual tissues? How does this pose a problem for the development of a chip system replicating this?

A

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37
Q

What is the goal when developing a system including the vascular system?

A

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38
Q

What is a way in which vascular system could be integrated?

A

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39
Q

What are 3D sacrificial moulding?

A

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40
Q

What is the criteria for 3D sacrificial moulding? What material satisfies these criteria?

A

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41
Q

What is a problem with the currently developed 3D sacrificial moulding lattices?

A

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42
Q

What is the method of the hepatic vascular system?

A

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43
Q

How was the hepatic vascular system’s efficacy tested? What was the experiment? What did it show?

A

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44
Q

In what way did the hepatic vascular system mimic the actual vascular system well?

A

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45
Q

How did the hepatic vascular system not mimic the actual vascular system well?

A

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46
Q

How was this problem overcome?

A

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47
Q

What was goal 2? How to create a diverse pool?

A

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48
Q

What happens if you have a skin biopsy from a patient? How do you generate several organs on chips for cross comparison?

A

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49
Q

How to difference IPSCs into cells of interest i.e. hepatocytes? What were the problem with these hepatocytes?

A

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50
Q

How was this problem solved?

A

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51
Q

What helped the foetal like hepatocytes mature?

A

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52
Q

How was the integrated cardiac and liver made?

A

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53
Q

What is this integrated cardiac and liver model show?

A

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Tissue Engineering and Regenerative Medicine (17 decks)

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