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Tissue Engineering and Regenerative Medicine > Lecture 11 > Flashcards

Lecture 11 Flashcards

1
Q

What is Motor Neuron Disease? What is the pathology? What muscles does it affect?

A

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2
Q

What are motor neurons? What is the structure?

A

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3
Q

What are astrocytes? What are the properties?

A

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4
Q

What are the causes of MND/ALS? What are the different mutations?

A

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5
Q

How to study MND/ALS?

A

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6
Q

How to treat MND/ALS?

A

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7
Q

What is the pathogenesis of MND/ALS of the different mutations?
a. C9orf72
b. SOD1
TDP-43

A

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8
Q

How did they test to see whether astrocytes were involved in the pathogenesis of MND/ ALS?

A

DASDASDSA

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9
Q

What factor of MND/ALS affects it’s treatment? What is the problem with this?

A

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10
Q

How has iPSCs change the field? What is the process used for ALS/MND?

A

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11
Q

How to differentiate into motor neurons and astrocytes?

A

ddadads

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12
Q

What can you do if can grow motor neurons and astrocytes in a dish?

A

dasdadasd

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13
Q

What are the different things which can be checked with the iPSCs in MND/ALS?

A

dasdadasd

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14
Q

What was the experiment which was done on ALS - IPSC derived astrocytes? What was expressed? Where was it found mostly? What was found to be the cause of the death of the motor neurons in this case?

A

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15
Q

What was the cause of death of motor neurons in the mutations of TDP-43? What were the properties of the motor neurons?

A

dasdasdad

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16
Q

What was used to test oxidative stress sensitivity?

A

DEASDADSADS

17
Q

What drug can be used to help this? How does it help it?

A

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18
Q

What was the alternative method to treat MND with a TDP-43 mutation?

A

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19
Q

What is the general method of working out how to treat a disease where do not know the mutation?

A

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20
Q

What are potential replacement strategies for MND/ALS?

A

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21
Q

What does the future hold? What needs to be worked on?

A

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Tissue Engineering and Regenerative Medicine (17 decks)

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