Lecture 4.1 Flashcards
Name three drugs which target ion channels
Lignocaine (lidocaine), Apamin, Nifidipine
Name three drugs which target enzymes
Captopril, pargyline/clorgyline, acetylsalicylic acid (aspirin)
Name two drugs which target transporters
Digoxin, fluoxetine
What is the main function of lignocaine?
local anesthetic (sore throat treatment is in strepsils)
What does lignocaine block?
Voltage gated Na channels
Where is apamin found in?
In bee venom
What is the function of apamin?
Causes pain if injected
What does apamin block?
K channels which are responsible for hyperpolarization
What group of drugs is nifedipine a part of?
Dihydropyridine
What is the function of nifedipine?
Used to manage high blood pressure
What does nifidepine block?
Calcium channels
What is the function of captopril?
Used to treat hypertension
What does captopril inhibit?
ACE
What is the function of pargyline/clorgyline?
Used as an antidepression
What does pargyline/clorgyline inhibit?
Irreversible and selective inhibitor of monoamine oxidase (MAO)
Where is Digoxin derived from?
Fox glove
What is the function of Digoxin?
Used to treat heart conditions e.g. atrial fibrillation
What does Digoxin inhibit?
Inhibits the Na/K ATPase, lengthening the cardiac action potential
What is fluoxetine also known as?
Prozac
What is the function of fluoxetine?
An antidepressant
What does fluoxetine inhibit?
Selective serotonin reuptake inhibitor
What is the function of acetylsalicylic acid?
Treatment for pain, fever and inflammation
What does acetylsalicylic acid inhibit?
Causes irreversible inactivation of cyclooxygenase (COX)
What group is acetylsalicylic acid a part of?
Type of NSAID
