Lecture 39 - Lymphoid Leukemias

Question 1

Acute Lymphoblastic Leukemia (ALL) presents very similar to Acute Myelogenous Leukemia, but which one is mostly seen in children, and which one is mostly seen in older adults?

Answer 1

ALL –> children

AML –> adults

Question 2

Acute leukemias are considered to show > ___% lymphoBLASTS in BM or PB.

Answer 2

> 20%

Question 3

ALL can be B or T-cell derived, but the latter typically occurs in _____ as opposed to children and presents as a thymic lymphoma.

Answer 3

Adolescents

Question 4

For Acute leukemias, the onset of symptoms is _____ (rapid or slow?).

Answer 4

Rapid –> about 2 weeks

Question 5

ALL cells show the pre B and T-cell marker ____.

Answer 5

Tdt

Question 6

Chronic Lymphocytic Leukemia (CLL) results in an accumulation of _____ B-lymphocytes. Small Lymphocytic Lymphoma (SLL) is basically the same thing, but the disease is considered CLL if WBC count > ______ cells/uL. Both CLL and SLL occur in _____, not children, and onset of symptoms is _____ (rapid or slow?). In these leukemias, the neoplastic cells exhibit increased _______ rather than proliferation –> What might these cells upregulate if this is the case? Also ____ cells can be observed on blood smear.

Keep in mind CLL can undergo Ritcher’s Transformation into ____ ____-cell Lymphoma.

Answer 6

Mature

> 5000 cells/uL

Adults

Slow

Survival

Bcl2

“Smudge”

Large B-cell Lymphoma

Question 7

Adult T-cell Leukemia/Lymphoma (ATLL) is an aggressive leukemia that presents in the _____ of patients. This cancer arises secondary to infection with which virus? –> the requirement for this infection is why this cancer is endemic to Japan, Caribbean, and West Africa. These patients will present with hyper______ and characteristic _____ cells that are CD4+ and CD25+.

Answer 7

Skin

Human T-cell Leukemia Virus Type 1 (HTLV-1)

Hypercalcemia

Flower (aka floret) cells