Lecture 32 - Antiplatelets

Question 1

ADP acts on platelets, causing upregulation of GP IIb-IIIa receptor that binds ______, generating platelet cross-links/facilitating aggregation.

Answer 1

Fibrinogen

Question 2

Know that Aspirin is an antiplatelet and remember what it inhibits. _____ is another antiplatelet drug that may be given in combination with apirin to patients who have had Percutaneous Coronary Intervention (PCI - aka angioplasty). It acts by permanently inhibiting the ADP receptor –> no upregulation of GP IIb-IIIa –> no platelet cross-linking.

Answer 2

Clopidogrel

Question 3

Vorapaxar is another antiplatelet that binds the _____1 receptor, which is where Thrombin would normally bind –> since it cannot bind, it cannot activate platelets.

Answer 3

PAR1 receptor

Question 4

Dipyridamole is an antiplatelet that acts by increasing ____ levels –> this lowers free calcium in the platelet –> inhibits vesicle fusion and granule release. Dipyridamole is given in combination with Warfarin ONLY to patients with _____ heart valves.

Answer 4

cAMP

Synthetic

Question 5

Tirofiban is an antiplatelet used only in hospitals and is given intravenously. It binds to the _____ receptor, blocking fibrinogen cross-linking of platelets.

Answer 5

GP IIb-IIIa