Lecture 36

Question 1

Iron Deficiency Anemia in adults should always raise a red flag for occult _____ cancer, until proven otherwise.

Answer 1

Colon cancer

Question 2

___ core lesion is a colon cancer manifestation that is observable with barium enema. The radiological image is exactly as the name suggests. Think about how this would change the shape of the stool.

Answer 2

Apple core lesion

Question 3

Painless ______ is another manifestation that should make you question if there is a cancerous blockage of the biliary duct.

Answer 3

Painless Jaundice

Question 4

Superior Vena Cava (SVC) Syndrome occurs as a result of obstruction of the Superior Vena Cava. Patients may present with “fullness” of head, arm swelling, and ______ (term that describes dark coloring from pooling of blood). It can result from Lung cancer tumors, thrombosis, or Lymphoma.

Answer 4

Plethora

Question 5

______ Syndrome is caused by Pancoast Tumor (a tumor of the superior sulcus of the lung). Patients present with issues pertaining to the ____ (typically dryness, non-reactive, droopy, etc…) bc the tumor affects the ______ chain.

Answer 5

Horner’s Syndrome

Parasympathetic

Question 6

Systemic Symptoms are also important clinical findings for recognizing cancers. What are the 3 B symptoms that are present in about 40% of Non-Hodgkin Lymphomas? Keep in mind these symptoms are likely a result of inflammatory cytokines like TNF-___, IL__, and IL__.

Answer 6

Fever, Weight loss, Sweats

TNF-Alpha, IL-1, and IL-6

Question 7

What is the protein produced in the kidney that elicits RBC production in the BM? Think about how a neoplasm in the kidney might result in Paraneoplastic Polycythemia.

Answer 7

EPO

Question 8

Another example of paraneoplastic syndrome is general weakness and fatigue symptoms of Myasthenia Gravis that results from a _____ (tumor of the thymus). The patients produce auto-Abs against the post-synaptic ACh receptor.

Answer 8

Thymoma

Question 9

Lambert-Eaton syndrome is very similar to Myasthenia Gravis in its presentation, except that the weakness and fatigue improve with ______. So which patients would you expect to get better throughout the day? Also be on the lookout for _____ dysfunction in males with Lambert-Eaton (LE) bc it affects the autonomic nervous system. About 50% of LE patients suffer from which cancer?

Answer 9

Exercise

Lambert-Eaton patients typically get better throughout the day.

Erectile dysfunction

Small-cell lung cancer

Question 10

Hypercalcemia is another frequently observed paraneoplastic syndrome, and it most often occurs secondary to _____ cell lung cancer (NOT SMALL-CELL). These cells produce _____ hormone-related peptide.

Answer 10

Squamous cell lung cancer

Parathyroid hormone-related peptide