Lecture 28 - Normocytic Anemia/Extrinsic Hemolysis

Question 1

Microangiopathic Hemolytic Anemia (MAHA) results in INTRAvascular hemolysis because of ______ formation throughout the vasculature. Consequently which component of blood is depleted (should make sense bc they form the thrombi) and what RBC shape (spherocytes or schistocytes) is observed in PB?

Answer 1

Thrombi

Platelets form the thrombi and thus are depleted. Schistocytes are observed in PB.

Question 2

TTP, HUS, and DIC are the three MAHAs. Which involve only platelets, and of those, which occurs in children and which one in adults?

Answer 2

TTP (Adults) and HUS (Children)

Question 3

Autoimmune hemolytic anemia can be Warm-reactive or Cold-reactive. Warm-reactive is mediated by Ig___, while Cold-reactive is mediated by Ig__.

Answer 3

IgG

IgM

Question 4

Alloimune hemolytic anemia can result from transfusion or in Hemolytic Disease of the ______ and _____. This type of anemia is detected with a positive result on which lab test?

Answer 4

Hemolytic Disease of the Fetus and Newborn

Positive result on Direct Antiglobulin Test (DAT)

Question 5

DAT detects RBCs sensitized with Ig___ in vivo, while Indirect Antiglobulin Test (IAT) requires incubation of patient’s RBCs with Ab.

Answer 5

IgG

Question 6

Aplastic anemia presents as a bone marrow failure anemia. It can be caused by autoimmune __-cell mediated reaction against hematopoietic stem cells (primary aplastic anemia), drugs or viruses (secondary), or it can be inherited (uncommon).

_____anemia and ____ _____ anemia are examples of inherited Aplastic Anemias. Which one results from a mutation in DNA repair, and which one results from a mutation in Ribosomal protein genes?

Answer 6

T-cell mediated

Fanconi Anemia

Diamond-Blackfan anemia

Fanconi –> DNA repair gene mutation

Diamond-Blackfan –> RIbosomal protein gene