Lecture 39 - AML

Question 1

AML patients might present with leukemic infiltration in the gums and renal failure secondary to _______ (results from tumor lysis syndrome). There are some congenital risk factors associated with AML. Of particular note is ______ syndrome. Also, patients who have histories of solid tumors and treatment with _____ agents and topoisomerases are at higher risk.

Answer 1

Hyperuricemia

Down syndrome

Alkylating agents

Question 2

AML cells produce a lot of myeloperoxidase which can become insoluble and present as ____ rods in these cells.

Answer 2

Auer rods

Question 3

The M3 subtype of AML arises from a 15;17 tranlocation that forms a fusion protein of Retinoic Acid Receptor-alpha and a growth suppressor PML. This fusion protein causes maturation arrest in the ______ stage. _____ is a drug that is used to treat this cancer by allowing transcription to occur which allows the cells to mature.

Answer 3

Promyelocytic stage

ATRA (All Trans Retanoic Acid)