LECTURE 3: Multiple Alleles

Question 1

MULTIPLE ALLELES

• definition

Answer 1

• more than 2 alleles at a single locus

Question 2

In a diploid individual, what is the:

• maximum number of alleles per locus?
• how many pairs of homologous chromosomes are responsible for the number of alleles per locus in diploid?

Answer 2

• max of 2
• 1 pair of homologous pair of chromosomes (each chromosome in the pair contributes one allele)

Question 3

Common Example of Multiple Alleles?

who discovered and when?

Answer 3

ABO Blood Group

• by Karl Landsteiner (1900)

Question 4

What is present in surface of RBC

and what is its 2 components?

Answer 4

GLYCOLIPID

• oligosaccharide +
• lipid

Question 5

What molecules determine the ABO blood types?

how?

Answer 5

the sequencing of oligosaccharide antigens

Question 6

Antigens of the following blood types:

1. A blood type
2. B blood type
3. AB blood type
4. O blood type

Answer 6

1. A
2. B
3. A and B
4. H

Question 7

SYNTHESIS OF OLIGOSACCHARIDE ANTIGENS for the ff antigens:

1. O
2. A
3. B

Answer 7

1. H antigen (a FUCOSE sugar: the 5th sugar)
2. A antigen (N acetyl galactosamine: the 6th sugar)
3. B antigen (galactosamine: the 6th sugar)

Question 8

What is the:

• universal donor
• universal receiver?

Answer 8

• blood type O
• blood type AB