Lecture 3 Flashcards

1
Q

What are the 3 types of studies

A
  1. Experimental models in health research (Animal models)
  2. Human studies; basic experimental design (Surveys without intervention. Clinic or not clinical)
  3. Evidence based medicine
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1
Q

Define in silico

A

Simulations with mathematical models/computes

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2
Q

Define in vitro

A

In glass - outside of living organisms

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3
Q

Define Ex vitro

A

Removing something from a living organism (Ex. dissecting the heart from a rat and studying it)

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4
Q

Define in vivo

A

Animal Model

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5
Q

What are the 4 experimental models in human research

A
  1. In silico
  2. In vitro and ex vitro models
  3. In vivo
  4. Human participants
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6
Q

Explain in silico experimental model

A

Done in early stages of understanding impact on health

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7
Q

Explain in vitro and ex vitro experimental model

A
  • Cell culture, isolated tissues/organs
  • Examples. Isolated and perfused (and beating) heart, growing skin (epidermis), transformed cancer cells, culturing cells, isolating rate soleus for incubators
  • Cells do not have to be animal cells, can be human cells
  • Allows for controlled experimental conditions
  • Understand fundamental mechanisms
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8
Q

Explain in vivo experimental model

A

Rats, pigs

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9
Q

Explain human participants experimental model

A
  • Using done last, hypothesis and generated for human trials
  • Someones done first if few ethical risks or lots of prior research
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10
Q

Explain preclinical vs clinical trials

A

Preclinical testing = in vitro, ex vitro, in vivo

Clinical testing = humans

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11
Q

What are the 2 main purposes of in vitro and ex vivo research

A
  1. Allows for more controlled experiment conditions
  2. Understanding fundamental mechanisms
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