Lecture 1 Flashcards

1
Q

What is systems biology

A

Systematic study of complex interactions in biological systems

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2
Q

Whats the goal of SB

A

To better understand entirety of the process that happens in a biological system

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3
Q

Is systems biology like the reductionist paradox

A

Opposite to reductionist paradox (looking at each component separately)

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4
Q

What does systems bio consider

A

Considers interactions and dynamics (complexity)

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5
Q

What are emergent properties

A

Properties of entire system that wouldn’t be evident if looking at individual component

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6
Q

What is an example of emergent properties

A

Ex. if looking at just serotonin, it would not allow us to describe our entire complex personality

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7
Q

What does SB incorporate

A

Genes to proteins to tissues to organ systems

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8
Q

Whats the main purpose of SB

A

Main purpose is to predict outcomes and responses in living system

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9
Q

Does SB include math?

A

Involves complex mathematical modeling. Referred to as bioinformatics

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10
Q

Define: geomics

A

Study of organisms complete set of DNA

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11
Q

Define: proteomics

A

Study of the set of all proteins produced within a biological unit; typically, this would be an organ, an organ system, or an entire organism

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12
Q

Define: metabolics

A

Study of metabolics within a given unit; eg. cell, tissue, organ, organism

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13
Q

Explain reductionist approach

A
  • Isolated molecules (ex. Individual organ)
  • Lots of control over experimental conditions
  • Used to understand mechanism of action
  • Don’t know what it means in vivo (living body)
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14
Q

Explain integrated approch

A
  • Whole body or organism approach
  • Less control over approach
  • Viewed as les mechanistic (ie, what factor was the most important)
  • More real world
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15
Q

Do reductionist and integration approch give same styles in outcomes

A

Sometimes using reduction vs integration in trials gives different outcomes

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16
Q

Example of trial with reductionist vs integrated approach

A
  • Stimulation of fat oxidation with anti-obesity hormone, leptin
  • Trial administered leptin to help with weight loss (reductionist approach)
  • Trials were totally successful
  • Obese and overweight people have become leptin resistant (integration approach)
17
Q

Are BP easy to predict

A

BP’s are complex and sometimes difficult to predict

18
Q

Are SB an integrated approach

A

SB is an integrated approach to better understand complexity of biology

19
Q

How are chronic diseases best studied

A

Most chronic diseases are very complex, affecting may systems and are best studied with SB approach