Lecture 24 antiviral procedures

Question 1

viral vaccines principle

Answer 1

block attachment

induce antibody production against RBP, neutralise virus

Question 2

types of vaccines

Answer 2

inactivated (main strain or related) heat, formaline

attenuated whole virus (avirulent main strain) unfavourable culturing

viral protein (surface antigens) heterologous system expression

Question 3

vaccine administration types

Answer 3

alone
species combination
strain combination

Question 4

enfuvirtide

Answer 4

block HIV fusion entry with PM

Question 5

amantadine

Answer 5

inhibit RNA release during influenza entry (exit endosome)

Question 6

genome replication antivirals

Answer 6

nucleoside, nucleotide, phosphate analogues

interfere viral genome synthesis

interrupt DNA/RNA chain elongation

ie azidothymidine inhibits HIV reverse transcription

Question 7

danoprevir

Answer 7

inhibit hep C NS3/4A protease, polyprotein processing (RdRp formation)

Question 8

oseltamivir

Answer 8

inhibit influena release by budding

Question 9

palivizumab

Answer 9

monoclonal antibody prevents dissemination within body for respiratory syncytial virus (RSV)

Question 10

interferon treatment

Answer 10

naturally produced by host cells genome cytoplasm release

innate 1st line

interferon stimulated genes expressed, stop viral dissemination