Lecture "12-13" MHC

Question 1

mhc1 structure

Answer 1

1 chain
noncovalent
α1,2 antigen bind
β2m stabilise
small antigens

Question 2

mhc2 structure

Answer 2

2chainz
α1,β1 antigen bind
large antigens

Question 3

mhc1 expression

Answer 3

nucleated cells

endogenous

Question 4

mhc2 expression

Answer 4

APC

acidic vesicle exogenous

Question 5

mhc polymorphisms

Answer 5

confined to peptide binding sites

MHC1 (α123)
MHC2(β12)
allow different antigen bind

Question 6

parent mhc inheritance

Answer 6

codominant expression
3 mhc1 per parent
3 mhc2 per parent

Question 7

mhc stability

Answer 7

antigen = stability
empty recycled or not sent surface

surface mhc self peptide

Question 8

mhc1 loading

Answer 8

proteosome degrade
degraded peptide to ER
chap stabilise MHC in ER
load sent to surface

Question 9

mhc2 loading

Answer 9

acidic phagolysosome
MHC prod in ER to PL
invariant chain chap stable degraded in acid
site loaded