Lecture 17 effector cells

Question 1

clonal selection

Answer 1

antigen specific lymphocytes proliferate

Question 2

b cell activation specificity

Answer 2

BCR native
MHC2 same peptide as native
th2 profile authorised by CD4

differentiate to plasma cell

Question 3

specific vs nonspecific B cell

Answer 3

specific = BCR bind antigen

10000x eff+ at MHC APC

Question 4

CD8 method of killing and help what other disease

Answer 4

apoptosis

serial tumour killer

Question 5

perforin and granzyme mechanism + ligand

Answer 5

polymeric cylindrical pore
granzyme enter pore
(protease cleaves proteins, induce apoptosis)
CD95L-CD95

Question 6

blebs

Answer 6

membrane

attract macrophage, neutrophil

Question 7

NK respond to, kill mechanism

Answer 7

missing self
low/no MHC1
apoptosis

Question 8

NK signalling

Answer 8

MHC activate inhibitoryR

overpower + signal from CAM&nucleated cell surface protein

Question 9

neonatal tolerance

Answer 9

immunocompromised, hardwired for tolerance

active central tol

treg surge, immunosuppressive cytokine secretion