Lecture 15 T cell biology

Question 1

th1

Answer 1

cytokine profile IFNγ

intracellular immunity

Question 2

th2

Answer 2

cytokine profile IL-4
extracellular immunity
stim B cell IgE (allergy, parasite)

Question 3

TCR generation of diversity

Answer 3

thymus germline no express
splicing
unique TCR (variable site)

Question 4

BCR vs TCR

Answer 4

unprocessed/native antigen
processed MHC antigen

both variable region are antigen binding

Question 5

TCR with receptors with diversity

Answer 5

mature, clonal

Question 6

principle of thymic selection

Answer 6

thymic stroma MHC1,2

test TCR self MHC binding

Question 7

3 types of TCR thymic selection

Answer 7

neglect zero
positive moderate
negative hypersensitive

Question 8

escape central tolerance

Answer 8

hypersensitive/autoreactive if 那 self antigen low expression

Question 9

transplant rejection

Answer 9

1-5% alloreactive

TCR hypersensitive to donor MHC/self peptide (as it were foreign peptide)

Question 10

self MHC restriction

Answer 10

positive selection for moderate self MHC binding

Question 11

self-self

Answer 11

autologous

Question 12

twins

Answer 12

syngeneic

Question 13

brothers

Answer 13

allogeneic