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MICR221 > Lecture 14 AP and costimulation > Flashcards

Lecture 14 AP and costimulation Flashcards

1
Q

increase TCR stability

A

DC ICAM-1
TC LFA-1

increase TCR-MHC adhesion

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2
Q

signal 1

A 
antigen presentation (MHC-TCR)
prereq ICAM-LFA pSMAC
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3
Q

serial triggering

A

MHC sleeps around
many TCR activated
+eff, rare complexes

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4
Q

signal 2

A

costimulation
DC express ONLY in danger CD80 (B7 family)

CD28 constant T

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5
Q

T cell smac

A

cSMAC (TCR, CD28)
pSMAC (LFA-1) (signal 0.5)
dSMAC (CD45, large, no contribution to adhesion)

AP at centre (cSMAC)

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6
Q

signal 1 + 2

A

T activate, proliferate

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7
Q

signal 1 only

A

anergy or apoptosis

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8
Q

TLR

A

TLR23459

lipoteichoic acid
dsRNA
lipopolysaccharide
flagellin
CpG
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9
Q

how does TLR provide danger signal to DC

A

upregulates costimulator (CD80) expression on DC

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MICR221 (22 decks)

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