Lecture 23 viral emergence

Question 1

ICTV classification

Answer 1

preferred

OFSGS

Question 2

baltimore classification

Answer 2

genome replication and mRNA synthesis

Question 3

viral emergence definition

Answer 3

newly appear in population,

existing but incidence/geographic range increasing

Question 4

viral emergence 2 steps

Answer 4

viral introduction (dead end)
dissemination within host population (established)

Question 5

ecological changes leading to viral emergence

Answer 5

contact with host (agriculture)

contact with intermediate host (vector) ie water ecosystem, global warming (mozz)

direct contact (flood, waterborne polio)

Question 6

human demographics/behaviour leading to viral emergence

Answer 6

stable virus-host interaction (population density, immunity status, urbanisation)
IV drug abuse, promiscuity

Question 7

international travel/trade

Answer 7

globalisation (food, airborne)

diminishing dead end virus host interaction

Question 8

virus change and adaptation

Answer 8

molecular change in virus-host interaction
RBP, RdRp mutation to infect, multiply human cells ie H5N1
proteins to antagonise innate defense ie poxvirus