Lecture 11 immune intro

Question 1

what does TLR bind to

Answer 1

flagellum
bacterial DNA
bacterial membrane

Question 2

what response does TLR activate

Answer 2

TF

inflammatory (cytokines)

Question 3

commensals vs pathogens

Answer 3

barriers keep out

intrinsically invasive

Question 4

gut vs commensals and pathogens

Answer 4

IgA

Question 5

adaptive immunity

Answer 5

slow
memory response fast
MHC dependent
lymphoid precursors dependent

Question 6

mechanism initiating adaptive immune system (what evolved)

Answer 6

phagocyte incomplete pathogen digestion surface display

Question 7

myeloid precursor

2 categories

Answer 7

eaters and iraqis

dendritic, macrophages vs neutrophil, mast cell

Question 8

macrophages

Answer 8

differentiated monocyte in tissue

Question 9

dendritic cell

Answer 9

tissue sentries

APC lymph node (B,T)

Question 10

lymphoid precursor maturation

Answer 10

T for thymus

B for bone marrow

Question 11

APC general activation schematic of lymphoid lineage

Answer 11

CD4 to CD8, B cell

Question 12

CD8 enzymes

Answer 12

perforin

granzyme

Question 13

antibody principle of action

Answer 13

antibody neutralise ptahogen or tags them

Question 14

clot vs non clotted

Answer 14

serum + clot

plasma, WBC, RBC