Lecture 16 B cell biology Flashcards
1
Q
antibody structure
A
heavy chain disulfide bond
light-heavy disulfide bond
2
Q
BCR binds
A
antigenic determinant on native antigen
3
Q
BCR= membrane bound
what structures present
A
IgM, IgD
Igα,Igβ aid signal transduction
4
Q
BCR diversity
A
no expression until antibody germline rearranged
mRNA splicing
unique variable region
5
Q
light vs heavy chain variable pool
A
VJ vs VDJ
50,25,5 (V,D,J)
6
Q
BCR changing type
A
lymph, spleen
downstream constant chains expressed
7
Q
B cell activation
A
BMHC2-CD4 TCR
th2 profile
8
Q
B cell loading MHC
A
MHC2 via receptor mediated endocytosis
9
Q
memory vs plasma B
A
BCR memory
no BCR plasma
10
Q
primary vs secondary response
A
10 days IgM, later IgG peak
3 days low IgM, later IgG extreme spike
11
Q
IgG
A
enter tissues
cross placenta
12
Q
IgM
A
complement
13
Q
IgE
A
allergy
parasite
14
Q
IgD
A
unknown
15
Q
IgA
A
serum monomer mucus dimer (secretory component)
