Lecture 18

Question 1

6 structures of synapse

Answer 1

presynaptic terminal
active zone
presynaptic vesicle
synaptic cleft
postsynaptic density
postsynaptic spine

Question 2

6 step of chemical synaptic transmission

Answer 2

action poteital invade presynaptic terminal, depolarize presynaptic terminal

voltage gated Ca channel open, Ca go into presynaptic terminal

concentration of Ca go up, activate a sequence of biochemical events

a few synaptic vesicle fuse with PM, dump content to synaptic cleft

neurotransmitter diffuse

neurotransmitter bind to ligand gated ion channel, depolarize post synaptic channel

Question 3

5 step of AMPA

Answer 3

action potential

presynaptic terminal depolarized

Ca channel open, vesicle fuse, dump glutamate

glutamate diffuse across synaptic cleft, bind to AMPA receptor

pore of AMPA open, Na flow in, depolarize post synaptic

Question 4

NMDA VS APMA

Answer 4

require glycine too
when open, make a pore permeable to Ca
plug by Mg

Question 4

how many EPSP must sum at initial segment to initiate an action potential

Answer 4

50-100

Question 5

high active excitatory synapse become stronger

Answer 5

synaptic plasticity