Lecture 07 Flashcards
3 plasma protein
fibrinogen, albumin, globulin
4 causes of edema
decreased plasma protein
increased hydrostatic pressure
increased capillary permeability
obstruction of lymphatic dranage
?=RBC; ?=platelet; ?=WBC
erythrocyte; thrombocyte; leukocyte
phrase for “cytokine that influence the proliferation and differentiation of blood cell precursors”
hematopoietic growth factor
general pattern of hematopoiesis
multipotential/ pluripotential stem cell self replication, leukopoiesis, thrombopoiesis, erythropoiesis
site of hematopoiesis
at yolk sac
blood precursor formed after fertilization, decline over a week
at liver and spleen
start at a month, peak at 5 month
at bone marrow
start halfway of pregnancy& continually produced after birth
at axial skeleton, particularly at flat
bone
after birth
distal long bone
at beginning a lot, decline to almost nothing at 20
axial skeleton
rest of life
axial skeleton有哪些
flat bone of skull, shoulder blade肩胛骨, sternum胸骨, vertebrae,椎骨 rib肋骨, pelvis骨盆, proximal epiphyses of long bones
the shaft of bone= ?; the proximal end& distal end of bone= ?
diaphysis骨干; epiphysis骨端
RBC reason(biconcave)
spectrin link the membrane and the cytoskeleton to be able to form flexible network
RBC advantage(biconcave)
maximal SA, minimal diffusion distance, squeeze through narrow capillary
CBC 是什么的缩写
complete blood clot
normal & abnormal RBC的5个单词(size&shape)
cell size
normocytic, microcytic, macrocytic
cell shape
sickle cell
spherocyte
RBC enzyme& function
glycolytic enzyme-generate E
carbonic anhydrase- CO2 to bicarbonate, easy to transport
hemoglobin strucutre
4 protein chain, 2 alpha, 2 beta
on each chain 1 heme region, Fe bind to heme region, O2 bind to heme
3 function of hemoglobulin
transport of O2
transport of CO2
buffer
why have hemoglobin inside RBC
otherwise COP increase, viscosity increase, small and easy to lost via kidney
M&F compare
M more blood, more RBC per ml, more hemoglobin per ml
5 factor affect ability of Hb to bind and release O2
T
ionic composition
pH
pCO2
intracellular enzyme conc
erythropoiesis 7步
kidney sense hypoxia, release erythopoietin
erythropoietin travel through blood stream and end up at bone marrow where stimulate production of RBC
take 3-5 days for division& differentiation of RBC
once the new RBC enter circulation, recognized as newborn blood cell/reticulocyte for 24 h
after 24h, indistinguishable from other RBC
increase in O2 capacity in plasma
kidney sense not hypoxia state, negative FB
factor determining #(RBC)
O2 requirement
O2 availability
