Lecture 16 Flashcards
Eupnea =
normal quiet breathing
Apnea =
temporary cessation of breathing
Dyspnea =
difficult or labored breathing
Diaphragmatic breathing =
descent of diaphragm causes stomach to bulge during inspiration
Costal breathing =
just rib activity involved
Tidal volume =
amount air moved during quiet breathing
MVR=
minute ventilation is amount of air moved in a minute
Reserve volumes —-
amount you can breathe either in or out above that amount of tidal volume
Residual volume =
1200 mL permanently trapped air in system
Vital capacity & total lung capacity are
sums of the other volumes
Air =
21% O2, 79% N2 and .04% CO2
Alveolar air =
14% O2, 79% N2 and 5.2% CO2
Expired air =
16% O2, 79% N2 and 4.5% CO2
Henry’s Law:
- Quantity of a gas that will dissolve in a liquid depends upon the amount of gas present and its solubility coefficient
- Breathing O2 under pressure dissolves more O2 in blood
Hyperbaric Oxygenation:
Use of pressure to dissolve more O2 in the blood
-anaerobic bacteria die in the presence of O2
External Respiration:
- Gases diffuse from areas of high partial pressure to areas of low partial pressure
- Exchange of gas between air & blood
- Deoxygenated blood becomes saturated
- Compare gas movements in pulmonary capillaries to tissue capillaries
Rate of Diffusion of Gases:
- Depends upon partial pressure of gases in air
- Large surface area of our alveoli
- Diffusion distance is very small
- Solubility & molecular weight of gases
O2 smaller molecule diffuses
somewhat faster
CO2 dissolves
24X more easily in water so net outward diffusion of CO2 is much faster
Internal Respiration:
- Exchange of gases between blood & tissues
- Conversion of oxygenated blood into deoxygenated
- Observe diffusion of O2 inward
- Observe diffusion of CO2 outward
acidosis =
more exhalation (volume and frequency) can help return to homeostasis. This is hyperventilation.
alkalosis =
less exhalation (volume and frequency) can help return to homeostasis (as can ‘rebreathing’ with a bag). This is hypoventilation.
Oxygen Transport in the Blood:
- Oxyhemoglobin contains 98.5% chemically combined oxygen and hemoglobin
- Does not dissolve easily in water
- Only the dissolved O2 can diffuse into tissues
Blood is almost fully saturated at
pO2 of 60mm
Between 40 & 20 mm Hg,
large amounts of O2 are released as in areas of need like contracting muscle
=
Bohr effect
As acidity increases, O2 affinity for Hb decreases
Acidity & Oxygen Affinity for Hb:
- Bohr effect
- H+ binds to hemoglobin & alters it
- O2 left behind in needy tissues
Temperature & Oxygen Release:
- As temperature increases, more O2 is released
- Metabolic activity & heat
- More biphosphoglycerate (BPG), more O2 released
Carbon Dioxide Transport:
100 ml of blood carries 55 ml of CO2
CO2 Is carried by the blood in 3 ways:
- dissolved in plasma
- combined with the globin part of Hb molecule forming carbaminohemoglobin
- as part of bicarbonate ion