Lecture 13 - B cells and their Response to Antigen Flashcards
B cells differentiate to
plasma cells
Plasma cells secrete
antibodies
Antibodies are also called ____ and are ____ with a common basic structure
Ig, glycoproteins
How many copies of identical BCRs does a B cell have
300,000
How many epitopes can one B cell recognize
1
B cell spends its life how
in search of its antigen
What happens if a B cell doesn’t encounter its antigen in 3-4 months
it will die
What happens if a B cell encounters its antigen
activated and expands clonally, some clones differentiate into plasma cells and some become long lived memory cells
What cells secrete antibodies
plasma cells
What do cytotoxic T cells recognize
processed epitopes by MHC I
What do helper T cells recognize
processed epitopes by MHC II
What do B cells recognize
native epitopes
What form the antigen binding site on the B cell
CDRs (complementariliy determining regions)
In addition to coming into contact with its antigen, what else can help activate a B cell
cytokines, stimulation of PRRs, Helper T cell contact, complement
How do B cells and Th cells interact
CD40 (B cell) and CD154 (Th cell) mediated dialog
How is the secondary antibody response different from primary
stronger and faster because there are memory cells, affinity maturation
Differentiate between T-dependent and T-independent antibody responses
T-dep: isotope switched, high-affinity antibodies, memory B cells, long-lived plasma cells
T-indep: mainly IgM, low affinity antibodies; short-lived plasma cells, no class switch, no memory
