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Microbiology Exam 2 > Lecture 13- Antibiotics pt.2 > Flashcards

Lecture 13- Antibiotics pt.2 Flashcards

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Biology 101 flashcards
1
Q

How do antibiotics that target folic acid work?

A

Competitive inhibition to block enzyme that creates folic acid

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2
Q

What do Sulfonamides do?

What do they target?

A
  • Competes with natural PABA and inhibit DNA replication
  • Folic acid
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3
Q

How do antibiotics that target cell membrane work?

A

Bind to LPS of gram negative bacteria

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4
Q

What is bad about Polymyxins?

What do they target?

A
  • Toxic to the kidneys
  • Cell membrane
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5
Q

How do antibiotics that target DNA/RNA work?

A

Target DNA gyrase in gram negative

Target topoisomerase in gram positive

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6
Q

What is bad about Quinolones?

What do they target?

A

Not recommended during pregnancy/for children

DNA/RNA

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7
Q

How do Rifamycins work?

What do they target?

A
  • Block RNA polymerase
  • DNA/RNA
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8
Q

Most antifungals are:

A

Fungistatic

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9
Q

How do Polyenes (antifungal) work?

A

Bind ergosterol in membrane

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10
Q

How do Macrolides (antifungal) work?

A

Treat systemic fungal infections

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11
Q

How do Azoles (antifungal) work?

A

Inhibit ergosterol synthesis

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12
Q

How do Euchinocandins (antifungal) work?

A

Damage cell wall of fungi

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13
Q

How do Flucytosine (antifungal) work?

A

Inhibit DNA replication

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14
Q

How do Quinine (Antiprotozoa) work?

A

Used for malaria parasite

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15
Q

What do mebendazole (antihelminth) work?

A

Inhibits metabolism in eggs

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16
Q

How do Praziquantel (antihelminth) work?

A

Paralyze fluke/tapeworms

17
Q

How do antiviral groups that prevent entry work?

A

Bind receptor to prevent fusion with host

18
Q

How do antivirals that prevent release work?

A

Inhibits neuraminidase for budding/releasing

19
Q

How do antivirals that prevent transcription/translation work?

What virus are they mainly used for?

A

Makes fake nucleotides that are incorporated and stops transcription.

Those exposed to HIV

20
Q

How do antivirals that prevent maturation work

A

Protease that stops viral assembly

Microbiology Exam 2 (18 decks)

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