Lecture # 11 MHC Presents Peptide Antigen to T Cells: MHC Restriction

Question 1

MHC I/MHC II

Answer 1

CD8+/ CD4+

Question 2

What is the role of polymorphism in MHC presentation?

Answer 2

Polymorphism contributes to the ability of the immune system to respond to many different and rapidly evolving pathogens (this makes it difficult for pathogens to evade presentation)

Question 3

Class I alpha chain genes

Answer 3

HLA-A, HLA-B, HLA-C

Question 4

Class II alpha and beta chain genes

Answer 4

HLA DQ, HLA-DR, HLA-DP

Question 5

On what chromosome is b2microglobulin

Answer 5

Chromosome 15. Remember Class I MHC has one MHC encoded gene and one non-MHC encoded gene.

Question 6

Class III MHC genes

Answer 6

Encode immune molecules: 1) Complement proteins (C4, Factor B, C2) 2) Cytokines: LTb, TNF-alpha, LT) Also encodes TAP

Question 7

What are MHC haplotypes? How are they inherited? What kind of dominance do they show?

Answer 7

MHC haplotypes are the genetic makeup of one’s MHC. They are inherited from parents and they are co-dominant.

Question 8

Haplotype

Answer 8

A haplotype is a set of DNA variations, or polymorphisms, that tend to be inherited together. A haplotype can refer to a combination of alleles or to a set of single nucleotide polymorphisms (SNPs) found on the same chromosome.

Question 9

Where are the polymorphisms in MHC?

Answer 9

Polymorphisms occur at peptide binding sites to accommodate different peptides.

Question 10

Mouse Class I

Answer 10

H-2k, H-2D, H-2L

Question 11

Mouse Class II

Answer 11

I-A, I-E