Jitt # 6 Questions And Answers

Question 1

The thymic equivalent of the bone marrow stromal cells are the thymic

Answer 1

epithelial cells

Question 2

Double positive thymocytes express

Answer 2

both CD4 and CD8

Question 3

The “surrogate light” chain that is expressed with newly rearranged β chain

Answer 3

is pTα chain

Question 4

Single positive T cells

Answer 4

are either mature Th or mature Tc cells

Question 5

To give nude mice a normal immune system one would have to

Answer 5

transplant a thymus

Question 6

The term MHC restriction refers to the:

Answer 6

requirement for antigen to be recognized in association with MHC molecules

Question 7

Double positive T cells with a transgenic TCR specific for HY (male) antigen on self Class I MHC

Answer 7

would develop into CD8+ T cells in female mice but it would not develop into mature T cells in male mice

Question 8

Positive and negative selection of T cells

Answer 8

must involve signals that differ either in amount or in type