Jitt # 5 Case # 12 MHC Class I Deficiency

Question 1

What class of MHC is located on all cells, except for RBCs?

Answer 1

Class I MHC; CD8+

Question 2

What kind of infections do MHC Class I/CD8+ fight against?

Answer 2

Viral infections

Question 3

What response do CD8+ cells have against MHC I cells expressing viral PAMPS?

Answer 3

1) Release Perforin (pore forming protein) 2) cytotoxic granzymes 3) TNF alpha 4) lymphotoxin

Question 4

What are the three types of Class I MHC in humans?

Answer 4

HLA-A, HLA-B, HLA-C

Question 5

What enzyme complex degrades viral DNA?

Answer 5

Proteasomes

Question 6

What proteins transport viral peptides from the cytosol into the ER?

Answer 6

TAP1 & TAP2; Both are located on the ER membrane

Question 7

Where are TAP 1 & TAP2 genes encoded?

Answer 7

In the region containing Class II genes

Question 8

TAPBP

Answer 8

Tapasin; facilitates the interaction of MHC I molecules with TAP1/2, and its antigenic peptides

Question 9

Bronchiectasis

Answer 9

Dialation of the bronchi from repeated infection

Question 10

CD19

Answer 10

B-Cells

Question 11

CD16

Answer 11

NK cells

Question 12

CD3

Answer 12

T Cells

Question 13

Non sense mutation

Answer 13

mutation that causes the translation of a mRNA segment prematurely

Question 14

MHC Class I Deficiency

Answer 14

Caused by a missense mutation in the gene that encoded TAP2; reduction in CD8+ T cells is caused by a reduction in the amount of MHC I expression. No MHC, No maturation.

Question 15

CD14

Answer 15

Macrophages