Jitt # 5 Case # 8 MHC Class II Deficiency

Question 1

MHC II presents antigens to which type of T-Cell

Answer 1

CD4+

Question 2

What type of peptides do MHC II molecules express? Meaning, what type of pathogens are involved in MHC II expression?

Answer 2

Extracellular pathogens or proteins, or pathogens that persist intracellularly inside vesicles

Question 3

What type of cells are MHC II molecules expressed on?

Answer 3

APCs; DC, macrophages, B lymphocytes, activated T-cells, activated epithelial cells, activated thymus * activated by interferon gama

Question 4

What type of cytokine upregulates the expression of MHC II molecules?

Answer 4

Interferon gamma

Question 5

What are the three classes of MHC II molecules?

Answer 5

DP, DQ, DR

Question 6

CD20

Answer 6

B Cells

Question 7

MHC II Deficiency

Answer 7

Low Ig levels; deficiency of CD4+ Cells Lack HLA-DR; autosomal recessive trait;

Question 8

What is a possible treatment for MHC II deficiency?

Answer 8

Bone marrow transplant, but the results are often unsatisfactory.