Jeopardy 11/24/15

Question 1

This CD4 T cell subset is important in maintaining tolerance in the periphery

Answer 1

What are Tregs?

Question 2

This dendritic cell expresses high levels of TLR7, TLR9 and secretes Type I interferons

Answer 2

Plasmacytoid DCs; Combat Viral infections

Question 3

T Cell production of this cytokine promotes IgG3 class switching:

Answer 3

IFNg

Question 4

What immunoglobulin class does IL-4 promote?

Answer 4

IgE

Question 5

All memory T cells express high levels of this marker

Answer 5

CD44

Question 6

What is the surface marker allows entry into the lymph node?

Answer 6

CD62L

Question 7

What is the chemokine receptor that allows naive T cells to migrate to the lymph node?

Answer 7

CCR7

Question 8

Which kinase phosphorylates ITAMS to begin the TCR signaling cascade?

Answer 8

What is LCK? ITAMS are the cytoplasmic tail of CD3, CD3 interacts with the TCR.

Question 9

DCs express this marker for migration from the tissues to the draining LN

Answer 9

CCR7

Question 10

The expression of this chemokine receptor promotes B and T cell migration to the follicle

Answer 10

CXCR5; present on T follicular helper cells (subset)

Question 11

B Cells require this type of CD4 T cell for effective memory responses

Answer 11

T follicular helper cells; if you knock these out, then memory B cell development is impaired.

Question 12

This molecule on activated T cells binds B7-1:B7-2 and signals cells to limit proliferation

Answer 12

CTLA-4

Question 13

This term refers to the ability of B cells to produce IgG, IgA or IgE after receiving T cell help

Answer 13

What is Class Switching

Question 14

This transcription factor “fixes” differentiation to the Th17 subset

Answer 14

What is ROR-gamma T

Question 15

What does Stat 3 do?

Answer 15

signal tranducers downstream from cytokine receptors. (IL-6 for Stat 3)

Question 16

This cytokine is produced after TCR signaling and CD28 ligation

Answer 16

What is IL-2? induces proliferation

Question 17

Tissue resident memory cells express this cell surface marker_______ while central memory cells express____________

Answer 17

for central memory cells: CCR7/CD62L/ CD44hi; Tissue resident memory cells CD103

Question 18

The idea that activated T cells demonstrate asymmetric proliferation in which one daughter cell becomes an effector and the other daughter cell becomes the memory cell is known as:

Answer 18

The bifurcative differentiation model

Question 19

Linear differentiation model

Answer 19

Assumes that memory cells are derived from effector cells.

Question 20

B7-1:B7-2 on the DC binds to this molecule on naive T cells

Answer 20

CD28

Question 21

Conventional, activated DC in the draining lymphn node participate in a non conventional mode of Ag presentation to activate naive CD8 T cells

Answer 21

What is cross presentation?

Question 22

This T helper subset secretes IFNg in response to viral infections

Answer 22

Th1

Question 23

Tissue resident DC express low levels of these markers compared to activated in the draining lymph node

Answer 23

MHCII/B71/2/IL-12/IL-2/IL-6/CCR7 for migration

Question 24

This cell surface marker (cytokine receptor) marks memory CD8 cells that participate in the recall response

Answer 24

IL-7R

Question 25

What two cytokines are important for maintaining CD8 Memory cells?

Answer 25

IL-7/IL-15

Question 26

Cells found in the sinus of the LN, good at phagocytosing large particulates

Answer 26

Macrophages

Question 27

Which cell is the best at receptor mediated endocytosis

Answer 27

B cell