Immunology Jeopardy

Question 1

This is produced by bone marrow stromal cells to induce development and proliferation of B lineage.

Answer 1

IL-7

Question 2

This cell comes from a common lymphoid progenitor but is considered part of the innate immune response

Answer 2

NK cells/ ILCs

Question 3

This cytosolic PRR cleaves IL-1 beta

Answer 3

The inflammasome NOD- Like receptors

Question 4

The first cell that enters an inflamed tissue from the blood

Answer 4

Tissue macrophages are there first, but the first cell that comes from the blood stream are neutrophils, monocytes come after neutrophils and are more numerous when they respond.

Question 5

The observation that a single antigen specific lymphocyte can undergo massive expansion/proliferation when binding specific antigen is a major tenent of the…

Answer 5

clonal expansion theory; (other tenets, non-reactivity to self, identical to parent cells, specific receptors

Question 6

The most variable portion of the heavy and light chains are in this area of the amino acid sequence

Answer 6

What is the hyper variable region/CDR3

Question 7

Viruses tend to induce the production of __________ after PRR engagement

Answer 7

Type I interferons ( include alpha and beta)

Question 8

This molecule is an important opsonin in the innate immune response

Answer 8

Mannose binding lectin

Question 9

What is an endocytic receptor?

Answer 9

Macrophage mannose receptor

Question 10

What is a type of signaling receptors?

Answer 10

TLRs

Question 11

What are some examples of cytosolic receptors?

Answer 11

RIG-1, NOD like receptor, MDA-5,

Question 12

___________ and __________ are adhesion molecules that participate in in tight binding of neutrophils to endothelium

Answer 12

LFA-1 (Neutrophil) ICAM-1 (Endothelium)

Question 13

This process occurs in the heavy chain locus during the Pro-B cell stage

Answer 13

DJ rearrangement first, and then V to DJ rearrangement.

Question 14

Heptamer and nonamer sequence where RAG-1 and RAG-2 bind?

Answer 14

RSS (Recombination signaling sequence)

Question 15

Location where adaptive immunity is activated

Answer 15

Lymph nodes/Spleen (secondary lymphoid organs)

Question 16

Intracellular pattern recognition receptor that recognizes viral RNA

Answer 16

(MDA-5, RIG-I, DAI) Activate transcription of interferons

Question 17

Expression of this cell surface molecule ensures progression past the first checkpoint

Answer 17

What is the pre-BCR receptor

Question 18

This arm of the immune response is evolutionarily conserved

Answer 18

The innate immune system

Question 19

B Cells develop in this central lymphoid organ

Answer 19

Bone Marrow

Question 20

Signaling through the Pre-B cell receptor induces these downstream events

Answer 20

light chain rearrangement, allelic exclusion (inhibition of heavy chain rearrangement), shutting off of surrogate light chains, cell proliferation. BTK induction

Question 21

What makes of the surrogate light chain?

Answer 21

lambda 5, V pre-B

Question 22

This cytokine has systemic effects on the liver, inducing acute phase proteins

Answer 22

IL-6

Question 23

What are the three pro-inflammatory cytokines

Answer 23

IL-1, IL-6, and TNF

Question 24

Cytokine that is most important for inducing vascular permeability

Answer 24

TNF

Question 25

What condition is TNF associated with.

Answer 25

Septic shock.

Question 26

Chemokine that induces neutrophil migration into tissue

Answer 26

CXCL1 and (CXCL8 THIS IS THE MAJOR ONE)

Question 27

CCL5

Answer 27

Mixed Leukocyte recruitment

Question 28

CCL19

Answer 28

T Cell and dendritic cell migration into parafollicular zones

Question 29

This enzyme is lymphocyte specific and catalyzes the VDJ recombination event

Answer 29

VDJ Recombinase (RAG-1/2); binds to RSS; TdT adds nucleotides, once RSS is clipped

Question 30

Ubiquitous enzymes in VDJ recombination

Answer 30

DNA-PK, Artemis, Ku70 & 80, DNA ligase,

Question 31

Type of pathogen generally recognized by cell surface PRRs

Answer 31

Bacterial; LPS TLRs 1,2,4,5,6

Question 32

LPS triggers this PRR in macrophages, leading to cytokine synthesis

Answer 32

CD14, TLR4

Question 33

B Cell receptor and antibodies are made up of these chains

Answer 33

heavy and light