lecture 10: limbic system Flashcards

1
Q

limbic lobe is a ______ structure that forms a ______ boundary when including the __________

A

cortical
circular
olfactory bulb & tract

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

limbic lobe does not share a boundary with which lobe?

A

occipital

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what are 3 main structures of the limbic lobe?

A
  • cingulate gyrus: ant & post
  • parahippocampal gyrus: entorhinal cortex
  • uncus: piriform cortex – primary olfactory cortex
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

the piriform cortex used to be called the __________ because it was thought that it played a role with the olfactory area but now it was found it doesn’t anymore

A

rhinencephalon

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what structure is directly related to the limbic system but is not classified as part of the limbic system?

A

cerebellum

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

true or false. we still use the Papez circuit to define the functions of the limbic system

A

false –> more things added to it. now called the spiral model

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what is emotion?

A

integrated physiological changes, behavioral reactions and feelings

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what are the two theories of emotion classification?
1) distinct _____ basic emotions
2) _______ with arousal level w/ neg. to post. valence –> aka you never have ________ emotion

A

1) 6
2) spectrum ; neutral

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

the hypothalamus forms the ________ wall of the _____ ventricle
it is located _______ to optic chiasm

A

anterolateral ; 3rd
superior

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

life and death functions of the hypothalamus:

A
  • homeostasis/initiation of drives (individual survival)
  • reproduction (species survival)
  • bridging endocrine and nervous systems
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

function of the 6 hypothalamic nuclei:
1. lateral nucleus:
2. ventromedial nucleus
3. posterior nucleus
4. anterior nucleus
5. paraventricular nucleus
6. supraoptic nucleus

A
  1. hunger center
  2. satiety center
  3. heating center
  4. cooling center
  5. produces oxytocin
  6. produces vasopressin ADH
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

neurohypophysis:
- location:
- developed from:
- stores & releases which two hormones?
- functions of these two collectively:

A
  • posterior pituitary
  • diencephalon
  • oxytocin (myometrium contraction & breast smooth muscle) AND ADH (water absorption & increase BP)
  • mating, bonding, brain development
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

adenohypophysis:
- location:
- developed from:
- what carries hormones to adenohypophysis?
- which hormones are released to the adenohypophysis?

A
  • anterior pituitary
  • posterior oral cavity (Rathke pouch)
  • hypophysial portal vein
  • thyrotropin-releasing, growth hormone-releasing, growth hormone release-inhibiting, corticotropin-releasing, gonadotropin-releasing, prolactin-releasing
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

temperature regulation reflex (intrinsic):
- specialized _______ neurons in hypothalamus
- normal blood temp. setpoint:
- when blood flows through the neurons & temp is detected, if the temp is lower than the setpoint, what is activated?
- when blood flows through the neurons & temp is detected, if the temp is higher than the setpoint, what is activated?
- rostral (ant.) hypothalamus function:
- caudal (post) hypothalamus function:

A
  • temp-sensing
  • 37 deg C
  • posterior nucleus (increase heat)
  • anterior nucleus (sweat to decrease heat)
  • heat dissipation (cool)
  • heat conservation/production (heat)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

what is happening when our body produces a fever?

A

cytokines/bacterial endotoxin increases the body temp past the setpoint –> increased temp will kill viruses

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what is happening to women’s bodies in postmenopausal syndrome?

A

irregular body temp setpoint –> setpoint changes due to loss of hormones

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

water balance reflex (neurohumoral):
- specialized ________ neurons in hypothalamus
- if plasma osmolarity is too high _____
- if plasma osmolarity is too low _____

A
  • osmolarity-sensing
  • increase ADH –> keep more water in
  • decrease ADH –> pee too much
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

_______ blocks ADH release –> urinates too much

A

alcoholism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

not enough ADH is released into the blood in a patient with ________

A

diabetes insipidus –> pee all the time

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Baroreceptor reflex (extrinsic):
- maintains:
- afferent signal:
- efferent signal to counteract:
- effect:

A
  • blood pressure
  • baroreceptors in carotid sinus (CN IX) and aortic arch (CN X) (increase BP)
  • CN X
  • decrease HR/BP
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

what structure can over-ride the baroreceptor reflex? typically needed in fight or flight situations when we need an increase in HR

A

hypothalamus

22
Q

functions of projections of the hypothalamus:
- medial frontal lobe:
- cerebellum:
- fornix –> amygdala:
–> hippocampus:
- thalamus:
- spinal cord/brainstem:

A
  • regulating drives/emotion
  • emotion/motor skill memory –> integration of somatic and visceral motors
  • 1: emotion 2: declarative memory
  • coordination
  • homeostasis and motor execution
23
Q

location of amygdala:
- ______ to inferior horn of lateral ventricle
- ______ to optical tract
- _______ to hippocampus

A
  • medial
  • lateral
  • anteromedial
24
Q

3 clusters of nuclei in amygdala:
- medial
- central
- basolateral

A
  • olfactory tract
  • hypothalamus and brainstem nuclei
  • different cortex region and sensory pathway
25
amygdala function in emotional learning: - _________ through experienced aversive stimuli directly (touch hot oven) - video, drawings, warnings - other emotional learning such as - memory enhancement effects have direct projection to ______ - memory enhancement effects function:
- fear conditioning - learned experience - reward-based learning - hippocampus - improving encoding, prevent extinction
26
fast track pathway: - sensory signals conducted to the ______ - projects to the _______ then initiates _______ - example?
thalamus amygdala ; motor reflexes - you see a toy spider (but you think it's real so you jump real fast)
27
fast track pathway is the _____ alert system --> includes all ______ modalities
1st sensory
28
cortico-amygdaloid pathway aka _____ pathway - you generate more information & analyze the situation --> you ____
slow relax ** not only one emotion center or purely emotion of fear
29
nucleus accumbens: - overall function: - location - part of the _____ - function of the shell: - function of the core:
- major reward center - ant. & ventral to the caudate and putamen - ventral striatum - pleasure - want/drive
30
reward seeking pathway: dopamine from __________ --> nucleus accumbens --> _____ ____ thalamic nuclei --> medial/ventral _______ ______ and anterior ______ ______
ventral tegmental area --> N.A --> dorsal medial thalamic nuclei --> med./vent prefrontal cortex and ant. cingulate gyrus
31
aversion pathway: ______ projections from __________ to ___________ and __________
direct ventral tegmental area ---> medial prefrontal cortex and anterior cingulate gyrus
32
Henry Molaison: - had several seizures resulting in bilateral temporal lobectomy. what did he lose & function loss?
hippocampus, most of amygdala and entorhinal cortex --> seizure managed but memory is compromised
33
as a result of the temporal lobectomy, Henry also lost some cerebellum. what medication treatment did he take for a while and what negative effect did that have on him?
- phenytoin for seizures - resulted in cerebellar atrophy
34
two parts of the hippocampus: 1. dentate gyrus: --> contains granule cells and _______ which regenerate the granule cells 2. hippocampus proper (cornu ammonis): --> contains ______ cells
- stem neuron cells - pyramidal cells
35
main input to hippocampus is from: main output from hippocampus proper is:
entorhinal cortex fornix
36
which type of amnesia (memory loss)? - no new memory formed ; can be short period like concussion or forever - loss of old memory ; generally short period
- anterograde amnesia - retrograde amnesia
37
two types of retrograde amnesia: - loss of more recent memory but intact with much older memory - damage of midline diencephalic structure, all memories impaired with various degrees
- temporal graded - flat gradient
38
how does Alzheimer's disease relate to amnesia?
varies from temporal graded to flat gradient amnesia
39
septal nuclei: - 2nd location of having _______ - injury to this area causes:
- stem cells --> still only regenerate granule cells - flat gradient amnesia
40
Korsakoff's disease/psychosis: - alcoholism abolished ______ and resulted in death of _______ - result of this disease: --> mainly ______ but some _______ amnesia
- VitB1 ; septal nuclei neurons (memory formation) - confabulation : anterograde amnesia with old memory mixed up as new memory --> anterograde but some graded retrograde
41
dissociation of memory pathways results in _______. a person with this (can/cannot) learn motor skills but can't explain how
no more memory formed can
42
what type of memory? - limited capacity, temporary storage, new information under encoding, not technically considered short term memory
working memory
43
what type of memory? - related to hippocampus and medial diencephalon, has two parts: episodic and semantic, a type of long-term memory, and functions for storage and retrieval of events, experiences, etc. w/ conscious awareness
declarative/explicit
44
what is episodic memory?
conscious recollection of personal experience about what/where/when it happened --> donor and dry lab
45
what is semantic memory?
general world knowledge and facts learned --> lecture
46
what type of memory? - related to cerebellum/amygdala/basal nuclei and cerebrum, type of long term memory that influences behaviors, skills, etc. without conscious awareness
nondeclarative, procedural, implicit
47
learning and storage of memory: - converting info for storage through short term memory - consolidation or transformation to long term memory - recall vs recognition
- encoding - storage - retrieval
48
principle NO 1 for storage of memory
all happens at the same association cortex where 1st time experience and 2nd time of retrieval happens
49
principle NO 2 for storage of memory
dissociation of memory --> lose some part of memory
50
true or false. amnesia is a result if ANY one of these steps of memory is impaired.
true