Lecture 10: Differentiation and Functions of CD4+ T cells Flashcards

1
Q

Langerhan’s cells are immature DCs which do not express high levels of

A

B7

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2
Q

Alpha/Beta chains of TCR have ____ intracellular domains

A

very short intracellular domains

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3
Q

CD3 proteins (gamma, delta, epsilon, and zeta) have ____ cytoplasmic tail

A

long

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4
Q

B7(CD80/CD86) are co-simulatory molecules expressed on

A

professional APCs

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5
Q

B7 moleces plug into CD___ on T cells

A
  • CD28
    • Co-simtulation can be consider as “an amplifier” that improve the signal
    • with co-stimulation, about 100 fold fewer of clustered TCRs are needed for activation
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6
Q

Subsets of CD4+ cells

A
  • Th1 cells
    • activate a cell-mediated immune response
  • Th2
    • activate an Ab-mediated immune response
  • Th17 cells
    • involved in inflammation and anti-bacterial response
  • Treg
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7
Q
A
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8
Q
A
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9
Q

cytokines derived from T cells

A
  • IL-2
    • T cell proliferation
    • Treg survival
  • IFN-gamma
    • activation of marophages
  • IL-4
    • B cell isotype switching to IgE
  • IL-5
    • Activation of Eosinophils
  • IL-17
    • Stimulation of acute inflammation
  • IL-22
    • Maintenance of epithelial barrier function
  • TGF-beta
    • Inhibition of T cell activation
    • differentiation of Treg cells
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10
Q

cytokines and transcription factors responsible for Th1 development

A
  • Cytokines
    • IL-12
    • IFN-gamma
  • Transcription factors
    • T-bet
    • STAT4
    • STAT1
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11
Q

Cytokines and Transcription factors responsible for Th2 development

A
  • Cytokine
    • IL-4
  • Transcription factor
    • GATA-3
    • STAT6
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12
Q

Cytokines and Transcription factors responsible for Th17 development

A
  • Cytokines
    • IL-1
    • IL-6
    • IL-23
    • TGF-beta
  • Transcription factors
    • RORgammat (orphan nuclear receptor)
    • STAT3
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13
Q

IFN-gamma produced by the Th1 cells amplifies Th1 development and inhibits the development of

A

Th2 and Th17

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14
Q

CD40L gene is located

A

on the X-chromosome

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15
Q

Nontraditional gamma/delta T cells do not express

A

They have TCRs and CD3 but do not express CD4 or CD8 coreceptors

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16
Q

Functions of gamma/delta T cells

A
  • First line of defense
  • regulatory cell
  • bridging between innate and adaptive responses
  • (note these cells are abundant in the intestine, the uterus, and the tongue)
  • (are considered component of both innate and adaptive immunity)
    • much less diverse than Alpha/beta TCRs
17
Q
A
18
Q

Lipids and glycolipids should be presented within non-polymorphic ____ molecule in order for NKT cells to identify them

A

CD1d

19
Q

Activated NKT cells produce large quantities of

A
  • IFN-gamma
  • IL-4
  • GM-CSF
20
Q

Dysfunction or deficiency of NKT lead to

A
  • Autoimmunity
  • Cancers
  • Progression of asthma