Lecture 10: Differentiation and Functions of CD4+ T cells Flashcards
Langerhan’s cells are immature DCs which do not express high levels of
B7
Alpha/Beta chains of TCR have ____ intracellular domains
very short intracellular domains
CD3 proteins (gamma, delta, epsilon, and zeta) have ____ cytoplasmic tail
long
B7(CD80/CD86) are co-simulatory molecules expressed on
professional APCs
B7 moleces plug into CD___ on T cells
- CD28
- Co-simtulation can be consider as “an amplifier” that improve the signal
- with co-stimulation, about 100 fold fewer of clustered TCRs are needed for activation
Subsets of CD4+ cells
- Th1 cells
- activate a cell-mediated immune response
- Th2
- activate an Ab-mediated immune response
- Th17 cells
- involved in inflammation and anti-bacterial response
- Treg
cytokines derived from T cells
- IL-2
- T cell proliferation
- Treg survival
- IFN-gamma
- activation of marophages
- IL-4
- B cell isotype switching to IgE
- IL-5
- Activation of Eosinophils
- IL-17
- Stimulation of acute inflammation
- IL-22
- Maintenance of epithelial barrier function
- TGF-beta
- Inhibition of T cell activation
- differentiation of Treg cells
cytokines and transcription factors responsible for Th1 development
- Cytokines
- IL-12
- IFN-gamma
- Transcription factors
- T-bet
- STAT4
- STAT1
Cytokines and Transcription factors responsible for Th2 development
- Cytokine
- IL-4
- Transcription factor
- GATA-3
- STAT6
Cytokines and Transcription factors responsible for Th17 development
- Cytokines
- IL-1
- IL-6
- IL-23
- TGF-beta
- Transcription factors
- RORgammat (orphan nuclear receptor)
- STAT3
IFN-gamma produced by the Th1 cells amplifies Th1 development and inhibits the development of
Th2 and Th17
CD40L gene is located
on the X-chromosome
Nontraditional gamma/delta T cells do not express
They have TCRs and CD3 but do not express CD4 or CD8 coreceptors