Lec 19 Animal Bites and Rabies Flashcards
Antibiotic therapy for bitten patients:
Treat bitten patient with a combination of B-lactams and B-lactamase inhibitors
5 proteins encoded by rabies virus
N, NS, M, G, L
Major influencing factors in the incubation period of Rabies.
- Virus load
- Virus strain
- Severity of exposure (multiple bites, size &
depth of bite) - Localization of exposure (the site of inoculation: the nearer to the brain, the shorter incubation period)
Non-specific symptoms of malaise, fatigue, headache, fever, nausea and vomiting, non-productive cough, anorexia, sore throat and paresthesia are experienced during which phase of RABIES?
Prodrome phase
Identify Clinical Manifestation Phase of RABIES:
· Excessive motor activity
· Excitation and agitation
· Confusion, hallucination, combativeness
· Bizarre aberration of thought, muscle spasms
Encephalic Phase
Identify Clinical Manifestation Phase of RABIES:
Hydrophobia
Brainstem Dysfunction Phase
Identify Clinical Manifestation Phase of RABIES:
Cranial nerve involvement
Respiratory center involvement
Brainstem Dysfunction Phase
Median survival period after onset of symptoms of Rabies.
4-20 days
Causes of death in Rabies patients
coma and apnea
The first rabies specific symptom
pain or paresthesia
Late complications of Rabies infection include:
a. SIADH
b. cardiac arrhythmia,
c. ARDS,
d. thrombocytopenia,
e. NOTA
f. AOTA
f. AOTA
Others:
diabetes insipidus, vascular instability, UGIB, Paralytic Ileus
Encephalitic vs Paralytic Rabies:
Fluctuating consciousness
Encephalitic
Encephalitic vs Paralytic Rabies:
Autonomic dysfunction
Encephalitic
Encephalitic vs Paralytic Rabies:
80% of Rabies cases
Encephalitic
Encephalitic vs Paralytic Rabies:
Complete paralysis and Guillain-Barre like symptoms
Paralytic
