Lec 18 Fever in the Immunocompromised Host

Question 1

dirtiest areas in our bodies

Answer 1

mouth and large intestine

Question 2

cytotoxic agent that affects VEGF

Answer 2

bevacizumab

Question 3

febrile neutropenia criteria

Answer 3

Fever of >38.30C OR sustained fever ≥ 380C for 1 hour or more

AND

Absolute neutrophil count

Question 4

cytotoxic agent that affects EGFR

Answer 4

cetuximab

Question 5

cytotoxic agent that affects CD33

Answer 5

gemtuzumab

Question 6

cytotoxic agent that affects HER2

Answer 6

trastuzumab

Question 7

Prevention for high-risk patients with expected durations of prolonged and profound neutropenia (Absolute Neutrophil Count

Answer 7

Fluoroquinolone Prophylaxis

Question 8

Prevention for those undergoing allogenic stem cell transplant and For those undergoing remission-induction or salvage induction chemotherapy for acute leukemia

Answer 8

Anti-Candida Prophylaxis

Question 9

Prevention for those undergoing extensive chemotherapy for acute myelogenous leukemia or myelodysplastic syndrome

Answer 9

Posaconazole Prophylaxis

Question 10

Prevention for herpes simplex virus (HSV)-positive patients undergoing allogenic stem cell transplant or leukemia induction therapy

Answer 10

Acyclovir Prophylaxis

Question 11

leading cause of cell-mediated immunity suppression

Answer 11

HIV

Question 12

Requires the least amount of immunosuppression among all transplant organs

Answer 12

kidney transplant

ps. pag nakarating ka na dito, pakyu ka

Question 13

Requires the highest amount of immunosuppression among all transplant organs

Answer 13

heart and intestines

Question 14

First-line immunosuppressants

Answer 14

Calcineurin Inhibitors and Anti-proliferative agents

Question 15

Immunosuppression peaks during the first ____ months post-transplant

Answer 15

6

Question 16

Used for autoimmune diseases such as inflammatory bowel disease, rheumatoid arthritis, and psoriasis.

Answer 16

TNF agonists

Question 17

targets CD20 found in B cells

Answer 17

rituximab

Question 18

Why does DM cause increased infection?

Answer 18

1. hyperglycemia effects
2. Breaks in cutaneous and mucosal barrier due to microvascular angiopathy
3. Neuropathy which diminishes pain sensation

Question 19

Immune changes as we get older

Answer 19

1. Functional change in T cell subsets, with a decrease in IL-2 secretion
2. Naive T cells have decreased ability to respond to new antigens
3. Humoral immunity mildly affected

Question 20

Which of these can cause impairments in antibody-mediated immunity?
A.	Multiple myeloma
B.	Chronic lymphocytic leukemia
C.	Splenectomy
D.	Rituximab treatment
E.	AOTA

Answer 20

E