Lec 03 Principles of Vaccinology and Guidelines Flashcards
T/F Vaccines save lives
F. No! Vaccination does!
T/F Vaccines must retain pathogenicity but not antigenicity.
F. Must maintain antigenicity and not pathogenicity
Non-specific and the body’s first line of defense
Innate Immunity
3 major characteristics of Adaptive Immunity
Memory, Specificity and Diversity
Active/Passive immunity?
Protection transferred from another person or animals
as antibody
Passive
Active/Passive immunity?
Usually permanent
Active
– substances added to inactivated vaccines
to increase host response and afford longer protection
Adjuvants
Live Attenuated/Inactivated?
MMR
Live attenuated
Live Attenuated/Inactivated?
BCG
Live attenuated (bacterial)
Protective immunity from inactivated vaccines develops after how many doses?
2-3
T/F: NO VACCINE IS COMPLETELY SAFE NOR COMPLETELY EFFECTIVE!
True
T/F: Simultaneous administration (administration on
the same day) of the most widely used live and inactivated vaccines doesn’t result in decreased antibody responses or increased rates of ADRs
T
There are NO contraindications to simultaneous administration of any vaccine except for cholera and?
Yellow fever
T/F: Increasing the interval between doses of a multidose
vaccine does diminishes the effectiveness of the
vaccine.
F
T/F: Decreasing the interval between doses of a multidose vaccine may interfere with antibody response and protection.
T
T/F: It is not necessary to restart the series of any vaccine
due to extended intervals between doses
T
Why are the buttocks not routinely used as a site for vaccination?
Possible injury to the sciatic nerve
Injection sites in the same limb should be separated by at least how many inches so local reactions will not overlap?
1 to 2
T/F If expiry date is Dec 2013, the vaccine is still viable until Dec 01, 2013.
F. Vaccine is viable until Dec 31, 2013
ALL vaccines are recommended to be transported and
stored at temperatures of:
2 to 8 degrees C
Identify severity of anaphylaxis:
Bronchospasm, stridor, collapse, hypotension, dysrhythmias
SEVERE
Identify severity of anaphylaxis:
Dizziness, perineal burning, warmth, pruritus
MILD
T/F: Tetanus vaccination of unprotected pregnant
women in developing countries is strongly recommended
T
Critical vaccination coverage for herd immunity (%) for Measles
92-95%
T/F: Inactivated vaccines are contraindicated in pregnant patients
F
