Lec 04 Adult Immunization

Question 1

Which influenza strain primarily affects children?

A. Type A
B. Type B
C. Type C
D. B & C only
E. AOTA

Answer 1

B. Type B

A - all ages, moderate-severe illness
B - primarily children, mild illness
C - rarely reported in human

Question 2

Which influenza vaccine is given intranasally?

A. inactivated trivalent vaccine
B. live attenuated trivalent vaccine
C. both
D. NOTA

Answer 2

B. live attenuated trivalent vaccine

Live vaccines are administered in a way that mimics natural infection.

Question 3

ID: Three strains present in the trivalent influenza vaccine.

Answer 3

AH3N2
AH1N1
B

Question 4

T/F: HIV-infected persons should be immunized against influenza.

Answer 4

T

But they should be given the INACTIVATED and not the live vaccine.

Question 5

ID: Common bacterial complication of both influenza and measles.

Answer 5

pneumococcal disease

Question 6

A second dose of pneumococcal vaccine is recommended for the following EXCEPT:

A. >65 y/o, first dose 5 years ago before age of 65
B.

Answer 6

E. NOTA

Question 7

ID: Serotype-specific antibody levels from pneumococcal vaccination decline after how many years?

Answer 7

5-10 years

Question 8

To what substance is the purified capsular polysaccharide of pneumococcus conjugated?

Answer 8

nontoxic diphtheria toxin

Question 9

Induce a T-cell response.

A. polysaccharide vaccine
B. conjugate vaccine
C. both
D. none

Answer 9

conjugate

Question 10

Higher antibody titers.

A. polysaccharide vaccine
B. conjugate vaccine
C. both
D. none

Answer 10

conjugate

Question 11

May be hyporesponsive.

A. polysaccharide vaccine
B. conjugate vaccine
C. both
D. none

Answer 11

polysaccharide

Question 12

Has booster effect.

A. polysaccharide vaccine
B. conjugate vaccine
C. both
D. none

Answer 12

conjugate

Question 13

This occurs in newborns when pregnant mothers become infected with varicella 5 days before to 2 days after delivery.

Answer 13

neonatal varicella - 30% fatality rate

Question 14

True of the current recommendations for varicella vaccination in adults.

A. 1 dose of varicella required for adults without evidence of immunity.
B. Post-vaccination serologic testing is recommended.
C. Can be given as post-exposure prophylaxis.
D. Can be given to pregnant women after the first trimester.
E. AOTA

Answer 14

C. post-exposure prophylaxis (if without evidence of immunity give within 72 hours of exposure)

A. 2 doses are recommended.
B. Post-vaccination serologic testing not recommended.
D. Cannot be given to pregnant women. Give AFTER pregnancy.

Question 15

T/F: Varicella vaccination can be considered in HIV-infected older children and adults with CD4 count of >200.

Answer 15

T. MMRV is not approved for HIV-infected persons but varicella vaccination may be considered if CD4 level is >200.

Question 16

T/F: Herpes zoster vaccine is indicated for treatment of zoster (shingles) and post-herpetic neuralgia (PHN).

Answer 16

F

Question 17

Herpes zoster vaccine (HZV) can be given simultaneously with:

A. influenza vaccine
B. pneumococcal vaccine
C. both
D. NOTA

Answer 17

A. influenza vaccine

Do not give with pneumococcal vaccine. It may result in reduced immunogenicity of HZV.

Question 18

Enumerate 3 other contraindications for varicella and zoster vaccination.

Answer 18

severe allergic reaction to vaccine components
pregnancy or planned pregnancy within 4 weeks
severe immunosuppression