Lec 08 Filariasis Flashcards
Filariasis is endemic in what regions?
tropical and sub-tropical regions
True of filarial worms
A. nematodes or roundworms B. live in the lymphatics C. transmitted by mosquito D. infective stage found in the mosquito E. B & C only F. AOTA
F. AOTA
What is the infective stage of filariasis?
L3 (third-stage filarial larva)
Enumerate the mosquito vectors of Wuchereria bancrofti.
Aedes
Anopheles
Culex
Enumerate the mosquito vectors of Brugia malayi.
Mansonia
Aedes
When is the best time to collect blood in a suspected filariasis patient?
A. morning
B. noon
C. evening
D. anytime
C. evening
nocturnal periodicity - release of microfilaria into the peripheral blood occurs at night
T/F: Microfilaria develops into the L1 (first-stage larva) in the human host.
F. They must be ingested by the mosquito vector to proceed to the larval stage.
What is the diagnostic stage of filarial worms?
microfilariae
True of Wuchereria bancrofti
A. smaller B. 2:1 cephalic length:breadth ratio C. 2 terminal nuclei D. gently curved body E. sheath pink
D. gently curved body
other choices are for Brugia malayi
Features of acute filariasis EXCEPT
A. dermatolymphangioadenitis
B. vomiting
C. fever
D. hydrocoele formation
D.
hydrocoele is a feature of CHRONIC filariasis
T/F: Worm may be dead in chronic filariasis.
T
The damage caused by adult worms is due to
obstruction of lymphatic drainage
T/F: Diagnosis is hinged on the isolation of adult worms.
F
You may introduce bacteria when doing biopsy in fibrotic / swollen tissues.
Do smear for microfilaria instead.
This has higher sensitivity.
A. thick blood smear
B. thin blood smear
C. kato katz smear
D. kato thick smear
A. thick blood smear
thin is for morphology and identification
yung kato smears ay para sa tae
What is the size of the nucleopore to be used in filtration?
5 micrometer
What is detected in the WB rapid and panLF rapid diagnostic test for filariasis?
IgG4
This can be seen upon ultrasound of hydrocoele / swollen scrotum.
dancing filaria / dance sign
Initial infection is dominated by
A. Th2
B. Th1
C. both
D. Th17
A. Th2
inflammatory phase = Th1
obstructive phase = both
The Th1 response against filaria is mediated by?
IFN-gamma
T/F: There is granuloma formation in chronic filariasis.
T
This drug is used for mass treatment of filarisis.
diethylcarbamazine (DEC)
Another anti-filarial drug not available in PH.
ivermectin
DEC is active against
A. microfilaria
B. adult worms
C. both
D. none, it’s for L2 larva
C. both
Why can’t doxycycline be a suitable replacement for DEC + albendazole?
long treatment (4-8 weeks) side effects (photosensitivity) cannot be used in children
But why is doxycycline used in the treatment of filariasis?
to kill Wolbachia, an obligatory symbiote inside filarial worms
