Lec 15 Typhoid Fever

Question 1

Triad of typhoid fever

Answer 1

Fever, headache, GI disturbance

Question 2

T/F: Presence of clinical symptoms characteristic of typhoid fever or the detection of a specific antibody response is definitive of typhoid fever.

Answer 2

F. Suggestive of typhoid fever but not definitive

Definitive lang pag may na isolate na S. typhi galing sa lesion or sa blood.

Question 3

Gold standard for the diagnosis of typhoid fever.

Answer 3

Blood culture

Question 4

Acute/Semi-acute/Convalescent Phase of Typhoid Fever?
IgM: +
IgG: -

Answer 4

Acute

Question 5

Acute/Semi-acute/Convalescence Phase of Typhoid Fever?
IgM: -
IgG: +

Answer 5

Convalescence

Question 6

Widely regarded as optimal for the treatment of typhoid fever in adults.

Answer 6

Fluoroquinolones

Question 7

Given in complicated cases of typhoid fever, because it is an antibiotic with a relative long half life. Given once a day.

Answer 7

ceftriaxone IV.

Question 8

Rate of carriage of S. typhi is higher among:

a. female patients,
b. patients older than 50 years
c. patients with cholelithiasis or schistosomiasis
d. AOTA
e. NOTA

Answer 8

d. AOTA

Question 9

A cook for several well-to-do families, seemed a healthy person when a health inspector knocked on her door in
1907, yet she was in actuality the cause of several deadly typhoid outbreaks.

a. HIV Adre
b. Typhoid Mary
c. STD Ron
d. Septic Carlos

Answer 9

b. Typhoid Mary

Question 10

S. typhi multiplies in:

Answer 10

Mononuclear phagocytic cells

Question 11

Pathognomonic sign of Typhoid fever

Answer 11

Rose spots (exanthem)

Question 12

Incubation period of S. typhi

Answer 12

8-14 days

Question 13

This capsule provides the basis for one of the commercially available vaccines against S. typhi.

Answer 13

Polysaccharide capsule Vi

Question 14

Fever lysis means patient has no fever for at least:

Answer 14

24 hours

Question 15

Suspect typhoid if there is fever of more than:

Answer 15

7 days

Question 16

Use of the 50 kD antigen to detect specific IgM and IgG

antibodies to S. typhi.

Answer 16

TYPHIDOT

Question 17

MDR Strains of S. typhi have resistance to:

Answer 17

Chloramphenicol,
Ampicillin
Trimethoprim-sulfamethoxazole

Question 18

T/F: Classic typhoid fever presents with absence of leukocytosis

Answer 18

T. Absence of leukocytosis is considered a criteria for typhoid. WBC count is normal or below normal. But, when patient presents with rising white blood cell count with a left shift and free air under the diaphragm on abdominal, consider intestinal perforation